Title: The conservation profile of a protein bears the imprint of the molecule that is evolutionarily coupled to the protein
Authors: Huang, Yu-Wen
Chang, Chih-Min
Lee, Chi-Wen
Hwang, Jenn-Kang
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
Keywords: protein structure;structural packing;sequence conservation;weighted contact number;nucleic acid binding protein
Issue Date: 1-Aug-2015
Abstract: The conservation profile of a protein is a curve of the conservation levels of amino acids along the sequence. Biologists are usually more interested in individual points on the curve (namely, the conserved amino acids) than the overall shape of the curve. Here, we show that the conservation curves of proteins bear the imprints of molecules that are evolutionarily coupled to the proteins. Our method is based on recent studies that a sequence conservation profile is quantitatively linked to its structural packing profile. We find that the conservation profiles of nucleic acid (NA) binding proteins are better correlated with the packing profiles of the protein-NA complexes than those of the proteins alone. This indicates that a nucleic acid binding protein evolves to accommodate the nucleic acid in such a way that the residues involved in binding have their conservation levels closely coupled with the specific nucleotides. Proteins 2015; 83:1407-1413. (c) 2015 Wiley Periodicals, Inc.
URI: http://dx.doi.org/10.1002/prot.24809
http://hdl.handle.net/11536/128017
ISSN: 0887-3585
DOI: 10.1002/prot.24809
Journal: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume: 83
Begin Page: 1407
End Page: 1413
Appears in Collections:Articles