Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Tsai-Wen | en_US |
dc.contributor.author | Hung, Yi-Tzu | en_US |
dc.contributor.author | Thikekar, Tushar | en_US |
dc.contributor.author | Paike, Vijaykumar V. | en_US |
dc.contributor.author | Lo, Fu Yuan | en_US |
dc.contributor.author | Tsai, Pei-Hua | en_US |
dc.contributor.author | Liang, Mei-Chih | en_US |
dc.contributor.author | Sun, Chung-Ming | en_US |
dc.date.accessioned | 2015-12-02T02:59:25Z | - |
dc.date.available | 2015-12-02T02:59:25Z | - |
dc.date.issued | 2015-08-01 | en_US |
dc.identifier.issn | 2156-8952 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1021/acscombsci.5b00001 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/128169 | - |
dc.description.abstract | A sequential single-flask multicomponent reactions is highly effective for the synthesis of 1,2-dihydroisoquinolines through amidealkylation from intermediate N-acylisoquinolinium salts under mild conditions. N-Acylisoquinolinium ions and trichloromethyl-1-(1H-indol-3-yl)isoquinoline-2(1H)-carboxylate have demonstrated their reactivity toward aromatic and aliphatic pi-nucleophiles. One of the 1,2-dihydroisoquinoline derivatives was found to be a potent inhibitor for transcription factor NF-kappa B by blocking I kappa B alpha degradation, p65 nuclear translocation, and NF-kappa B DNA binding in TNF-alpha-induced NIH 3T3 cells. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | dihydroisoquinolines | en_US |
dc.subject | transcription factor NP-kappa B | en_US |
dc.subject | p65 nuclear translocation | en_US |
dc.subject | amidealkylation | en_US |
dc.subject | DNA binding | en_US |
dc.subject | 3T3 cells | en_US |
dc.title | Telescoped Synthesis of 2-Acyl-1-aryl-1,2-dihydroisoquinolines and Their Inhibition of the Transcription Factor NF-kappa B | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1021/acscombsci.5b00001 | en_US |
dc.identifier.journal | ACS COMBINATORIAL SCIENCE | en_US |
dc.citation.volume | 17 | en_US |
dc.citation.spage | 442 | en_US |
dc.citation.epage | 451 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 應用化學系 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Department of Applied Chemistry | en_US |
dc.identifier.wosnumber | WOS:000359498900003 | en_US |
dc.citation.woscount | 0 | en_US |
Appears in Collections: | Articles |