標題: Quantiferon TB-Gold conversion can predict active tuberculosis development in elderly nursing home residents
作者: Tsou, Ping-Hsien
Huang, Wei-Chang
Huang, Chen-Cheng
Lin, Chen-Fu
Wu, Kun-Ming
Hsu, Jeng-Yuan
Shen, Gwan-Han
生物科技學系
Department of Biological Science and Technology
關鍵字: elderly;Mycobacterium tuberculosis;nursing home residents;Quantiferon TB-Gold assay;tuberculin skin test
公開日期: 1-十月-2015
摘要: AimThe study was carried out on elderly nursing home residents in Taiwan. We assessed whether the serial QuantiFERON-TB Gold (QFT-G) assay and serial tuberculin skin test (TST) were reliable tools to predict or exclude the development of active tuberculosis (TB). MethodsThis prospective observational cohort study involved non-bacillus Calmette-Guerin-vaccinated 259 elderly nursing home residents free of active TB at baseline. Of these, 147 were eligible for follow up. Participants underwent serial QFT-G and TST at baseline and 2-year follow up, and were monitored for active TB over 5years. Agreement between QFT-G and TST, incidence rate ratio, positive predictive value, and negative predictive value for progression to active TB were measured. ResultsDuring 5-year follow up, three participants developed active TB. The agreement between these two tests was 54.13% (?=0.167, P=0.001). The incidence rate ratio was 15.8 (P=0.016) for the QFT-G-conversion group compared with the TST-positive group at baseline. Positive predictive value for QFT-G conversion groups was 25%. Negative predictive value was 100% for the TST-negative group at baseline. ConclusionIn the elderly nursing home residents, QFT-G conversion is a more reliable tool to predict the development of active TB. Meanwhile, TST is a valuable tool for predicting the chance of not developing active TB. Geriatr Gerontol Int 2015; 15: 1179-1184.
URI: http://dx.doi.org/10.1111/ggi.12416
http://hdl.handle.net/11536/128233
ISSN: 1444-1586
DOI: 10.1111/ggi.12416
期刊: GERIATRICS & GERONTOLOGY INTERNATIONAL
Volume: 15
Issue: 10
起始頁: 1179
結束頁: 1184
顯示於類別:期刊論文