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dc.contributor.authorLin, Jiun-Nongen_US
dc.contributor.authorChang, Lin-Lien_US
dc.contributor.authorLai, Chung-Hsuen_US
dc.contributor.authorHuang, Yi-Hanen_US
dc.contributor.authorChen, Wei-Fangen_US
dc.contributor.authorYang, Chih-Huien_US
dc.contributor.authorHsu, Janineen_US
dc.contributor.authorLin, Hsi-Hsunen_US
dc.contributor.authorChen, Yen-Hsuen_US
dc.date.accessioned2015-12-02T02:59:29Z-
dc.date.available2015-12-02T02:59:29Z-
dc.date.issued2015-10-01en_US
dc.identifier.issn0732-8893en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.diagmicrobio.2015.06.018en_US
dc.identifier.urihttp://hdl.handle.net/11536/128255-
dc.description.abstractFluoroquinolone-nonsusceptible Streptococcus pyogenes has rapidly emerged in several countries. The aim of this study was to survey the epidemiology and molecular characteristics of fluoroquinolone-nonsusceptible S. pyogenes in Taiwan. A total of 350 consecutive S. pyogenes isolates were collected between January 2005 and December 2012, including 152 (43.4%) invasive and 198 (56.6%) noninvasive isolates. Thirty-nine isolates (11.1%) of S. pyogenes were nonsusceptible to fluoroquinolones, including one emm1/ST28, 4 emm4/ST39, 33 emm12/ST36, and 1 emm87/5T62. Of all the isolates, emm12 (50%) demonstrated the highest prevalence of fluoroquinolone nonsusceptibility. Alterations of Ser79Phe and Ala12Val in ParC were the most frequently mutations in fluoroquinolone-nonsusceptible S. pyogenes isolates. There were no amino acid substitutions in GyrB, and 1 emm87 isolate exhibited 3 nonsynonymous mutations in ParE. Our study reveals the emergence of fluoroquinolone-nonsusceptible S. pyogenes emm12/ST36 in Taiwan. Regular surveillance of fluoroquinolone susceptibility in S. pyogenes is suggested. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectStreptococcus pyogenesen_US
dc.subjectGroup A streptococcusen_US
dc.subjectFluoroquinolone resistanceen_US
dc.subjectQuinolone resistance-determining regionsen_US
dc.titleHigh prevalence of fluoroquinolone-nonsusceptible Streptococcus pyogenes emm12 in Taiwanen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.diagmicrobio.2015.06.018en_US
dc.identifier.journalDIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASEen_US
dc.citation.volume83en_US
dc.citation.spage187en_US
dc.citation.epage192en_US
dc.contributor.department生醫工程研究所zh_TW
dc.contributor.departmentInstitute of Biomedical Engineeringen_US
dc.identifier.wosnumberWOS:000362312100020en_US
dc.citation.woscount0en_US
Appears in Collections:Articles