標題: Supramolecular Assembly Mediates the Formation of Single-Chain Polymeric Nanoparticles
作者: Cheng, Chih-Chia
Chang, Feng-Chih
Yen, Hsiu-Che
Lee, Duu-Jong
Chiu, Chih-Wei
Xin, Zhong
應用化學系
Department of Applied Chemistry
公開日期: 1-十月-2015
摘要: A breakthrough innovation in water-based polymeric nanoparticles has enabled significant progress in mimicking the folding of natural proteins by generating novel "single-chain polymeric nanoparticles" (SCPNs) via supramolecular interactions. In this study, a practical approach to the living polymerization of functionalized oligo(ethylene glycol) methacrylate monomers allows the incorporation of self-constituted multiple hydrogen-bonded groups into physically cross-linked polymer networks, which enables the formation of highly functionalized SCPNs in an aqueous environment. The newly developed materials are particularly attractive from a practical point of view since they have a very low critical micellization concentration and uniform particle diameters of ca. 25 nm, making them extremely stable under dilute conditions. Concentration-dependent experiments showed that SCPNs formed at polymer concentrations up to 40 mg/mL with no significant change in morphology observed. Moreover, the formed SCPNs had a very high stability in an aqueous solution containing surfactant, suggesting potential for a wide variety of applications as a promising candidate nanocarrier for bioimaging, controlled release, and drug delivery systems.
URI: http://dx.doi.org/10.1021/acsmacrolett.5b00556
http://hdl.handle.net/11536/128429
ISSN: 2161-1653
DOI: 10.1021/acsmacrolett.5b00556
期刊: ACS MACRO LETTERS
Issue: 10
起始頁: 1184
結束頁: 1188
顯示於類別:期刊論文