標題: | Supramolecular Assembly Mediates the Formation of Single-Chain Polymeric Nanoparticles |
作者: | Cheng, Chih-Chia Chang, Feng-Chih Yen, Hsiu-Che Lee, Duu-Jong Chiu, Chih-Wei Xin, Zhong 應用化學系 Department of Applied Chemistry |
公開日期: | 1-十月-2015 |
摘要: | A breakthrough innovation in water-based polymeric nanoparticles has enabled significant progress in mimicking the folding of natural proteins by generating novel "single-chain polymeric nanoparticles" (SCPNs) via supramolecular interactions. In this study, a practical approach to the living polymerization of functionalized oligo(ethylene glycol) methacrylate monomers allows the incorporation of self-constituted multiple hydrogen-bonded groups into physically cross-linked polymer networks, which enables the formation of highly functionalized SCPNs in an aqueous environment. The newly developed materials are particularly attractive from a practical point of view since they have a very low critical micellization concentration and uniform particle diameters of ca. 25 nm, making them extremely stable under dilute conditions. Concentration-dependent experiments showed that SCPNs formed at polymer concentrations up to 40 mg/mL with no significant change in morphology observed. Moreover, the formed SCPNs had a very high stability in an aqueous solution containing surfactant, suggesting potential for a wide variety of applications as a promising candidate nanocarrier for bioimaging, controlled release, and drug delivery systems. |
URI: | http://dx.doi.org/10.1021/acsmacrolett.5b00556 http://hdl.handle.net/11536/128429 |
ISSN: | 2161-1653 |
DOI: | 10.1021/acsmacrolett.5b00556 |
期刊: | ACS MACRO LETTERS |
Issue: | 10 |
起始頁: | 1184 |
結束頁: | 1188 |
顯示於類別: | 期刊論文 |