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dc.contributor.authorChang, Feng-Yuen_US
dc.contributor.authorTsai, Meng-Tsanen_US
dc.contributor.authorWang, Zu-Yien_US
dc.contributor.authorChi, Chun-Kaien_US
dc.contributor.authorLee, Cheng-Kuangen_US
dc.contributor.authorYang, Chih-Hsunen_US
dc.contributor.authorChan, Ming-Cheen_US
dc.contributor.authorLee, Ya-Juen_US
dc.date.accessioned2019-04-03T06:36:11Z-
dc.date.available2019-04-03T06:36:11Z-
dc.date.issued2015-11-16en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dx.doi.org/10.1038/srep16739en_US
dc.identifier.urihttp://hdl.handle.net/11536/129382-
dc.description.abstractBlood coagulation is the clotting and subsequent dissolution of the clot following repair to the damaged tissue. However, inducing blood coagulation is difficult for some patients with homeostasis dysfunction or during surgery. In this study, we proposed a method to develop an integrated system that combines optical coherence tomography (OCT) and laser microsurgery for blood coagulation. Also, an algorithm for positioning of the treatment location from OCT images was developed. With OCT scanning, 2D/3D OCT images and angiography of tissue can be obtained simultaneously, enabling to noninvasively reconstruct the morphological and microvascular structures for real-time monitoring of changes in biological tissues during laser microsurgery. Instead of high-cost pulsed lasers, continuous-wave laser diodes (CW-LDs) with the central wavelengths of 450 nm and 532 nm are used for blood coagulation, corresponding to higher absorption coefficients of oxyhemoglobin and deoxyhemoglobin. Experimental results showed that the location of laser exposure can be accurately controlled with the proposed approach of imaging-based feedback positioning. Moreover, blood coagulation can be efficiently induced by CW-LDs and the coagulation process can be monitored in real-time with OCT. This technology enables to potentially provide accurate positioning for laser microsurgery and control the laser exposure to avoid extra damage by real-time OCT imaging.en_US
dc.language.isoen_USen_US
dc.titleOptical coherence tomography-guided laser microsurgery for blood coagulation with continuous-wave laser diodeen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep16739en_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.citation.volume5en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department光電系統研究所zh_TW
dc.contributor.departmentInstitute of Photonic Systemen_US
dc.identifier.wosnumberWOS:000364680800002en_US
dc.citation.woscount5en_US
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