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dc.contributor.authorXu, Yu-Juanen_US
dc.contributor.authorCheng, Jason Chia-Hsienen_US
dc.contributor.authorLee, Jang-Mingen_US
dc.contributor.authorHuang, Pei-Mingen_US
dc.contributor.authorHuang, Guan-Huaen_US
dc.contributor.authorChen, Cheryl Chia-Huien_US
dc.date.accessioned2016-03-28T00:04:12Z-
dc.date.available2016-03-28T00:04:12Z-
dc.date.issued2015-10-01en_US
dc.identifier.issn1083-7159en_US
dc.identifier.urihttp://dx.doi.org/10.1634/theoncologist.2015-0178en_US
dc.identifier.urihttp://hdl.handle.net/11536/129419-
dc.description.abstractBackground. Preserving functional walking capacity and nutritional status is important for patients with esophageal cancer, but no effective intervention is available, particularly during active treatment. Methods. This pilot randomized controlled trial tested the effects of a walk-and-eat intervention for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. Participants with locally advanced esophageal cancer stage IIB or higher (n = 59) were randomly assigned to receive the walk-and-eat intervention (n = 30; nurse-supervised walking three times per week and weekly nutritional advice) or usual care (n = 29; control group) during 4-5-weeks of chemoradiotherapy. Primary endpoints were changes in distance on the 6-minute walk test, hand-grip strength, lean muscle mass, and body weight between initiation and completion of intervention. Results. Participants (mean age: 59.6 years) were mostly male (92.9%) with squamous cell carcinoma (96.4%). During chemoradiotherapy, participants who received the walk-and- eat intervention had 100-m less decline than controls in walk distance (adjusted p = .012), 3-kg less decrease in hand-grip strength (adjusted p = .002), and 2.7-kg less reduction in body weight (adjusted p < .001), regardless of age. The intervention group also had significantly lower rates of need for intravenous nutritional support and wheelchair use. Conclusion. The nurse-led walk-and-eat intervention is feasible and effective to preserve functional walking capacity and nutritional status for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy.en_US
dc.language.isoen_USen_US
dc.subjectRandomized controlled trialen_US
dc.subjectEsophageal canceren_US
dc.subjectNeoadjuvant therapyen_US
dc.subjectExerciseen_US
dc.subjectNutritionen_US
dc.titleA Walk-and-Eat Intervention Improves Outcomes for Patients With Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapyen_US
dc.typeArticleen_US
dc.identifier.doi10.1634/theoncologist.2015-0178en_US
dc.identifier.journalONCOLOGISTen_US
dc.citation.volume20en_US
dc.citation.issue10en_US
dc.citation.spage1216en_US
dc.citation.epage1222en_US
dc.contributor.department統計學研究所zh_TW
dc.contributor.departmentInstitute of Statisticsen_US
dc.identifier.wosnumberWOS:000366041500018en_US
dc.citation.woscount0en_US
Appears in Collections:Articles