完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chao, Shih-Chun | en_US |
dc.contributor.author | Vagaggini, Tommaso | en_US |
dc.contributor.author | Nien, Chan-Wei | en_US |
dc.contributor.author | Huang, Sheng-Chieh | en_US |
dc.contributor.author | Lin, Hung-Yu | en_US |
dc.date.accessioned | 2019-04-03T06:36:12Z | - |
dc.date.available | 2019-04-03T06:36:12Z | - |
dc.date.issued | 2015-01-01 | en_US |
dc.identifier.issn | 2090-004X | en_US |
dc.identifier.uri | http://dx.doi.org/10.1155/2015/152854 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/129453 | - |
dc.description.abstract | The effects of lutein and zeaxanthin on lipopolysaccharide-(LPS-) induced secretion of IL-8 by uveal melanocytes (UM) were tested in cultured human UM. MTT assay revealed that LPS (0.01-1 mu g/mL) and lutein and zeaxanthin (1-10 mu M) did not influence the cell viability of cultured UM. LPS caused a dose-dependent increase of secretion of IL-8 by cultured UM. Lutein and zeaxanthin did not affect the constitutive secretion of IL-8. However, lutein and zeaxanthin decreased LPS-induced secretion of IL-8 in cultured UM in a dose-dependent manner. LPS significantly increased NF-kappa B levels in cell nuclear extracts and p-JNK levels in the cell lysates from UM, but not p-p38 MAPK and p-ERG. Lutein or zeaxanthin significantly reduced LPS-induced increase of NF-kappa B and p-JNK levels, but not p38 MAPK and ERG levels. The present study demonstrated that lutein and zeaxanthin inhibited LPS-induced secretion of IL-8 in cultured UM via JNK and NF-kappa B signal pathways. Theanti-inflammatory effects of lutein and zeaxanthin might be explored as a therapeutic approach in the management of uveitis and other inflammatory diseases of the eye. | en_US |
dc.language.iso | en_US | en_US |
dc.title | Effects of Lutein and Zeaxanthin on LPS-Induced Secretion of IL-8 by Uveal Melanocytes and Relevant Signal Pathways | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1155/2015/152854 | en_US |
dc.identifier.journal | JOURNAL OF OPHTHALMOLOGY | en_US |
dc.citation.spage | 0 | en_US |
dc.citation.epage | 0 | en_US |
dc.contributor.department | 電機工程學系 | zh_TW |
dc.contributor.department | Department of Electrical and Computer Engineering | en_US |
dc.identifier.wosnumber | WOS:000364850400001 | en_US |
dc.citation.woscount | 4 | en_US |
顯示於類別: | 期刊論文 |