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dc.contributor.authorTang, Yih-Jingen_US
dc.contributor.authorHo, Shinn-Yingen_US
dc.contributor.authorChu, Fang-Yingen_US
dc.contributor.authorChen, Hung-Anen_US
dc.contributor.authorYin, Yun-Juen_US
dc.contributor.authorLee, Hua-Chinen_US
dc.contributor.authorChu, William Cheng-Chungen_US
dc.contributor.authorYeh, Hui-Wenen_US
dc.contributor.authorChiang, Wei-Shanen_US
dc.contributor.authorYeh, Chia-Lunen_US
dc.contributor.authorHuang, Hui-Lingen_US
dc.contributor.authorTzeng, Nian-Shengen_US
dc.date.accessioned2019-04-03T06:44:53Z-
dc.date.available2019-04-03T06:44:53Z-
dc.date.issued2015-12-30en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0146030en_US
dc.identifier.urihttp://hdl.handle.net/11536/129522-
dc.description.abstractBackground We conducted a study using a case-crossover design to clarify the risk of acute effects of zolpidem and benzodiazepine on all-sites of fractures in the elderly. Design of study Case-crossover design. Methods and Materials Elderly enrollees (n = 6010) in Taiwan's National Health Insurance Research Database with zolpidem or benzodiazepine use were analyzed for the risk of developing fractures. Results After adjusting for medications such as antipsychotics, antidepressants, and diuretics, or comorbidities such as hypertension, osteoarthritis, osteoporosis, rheumatoid arthritis and depression, neither zolpidem nor benzodiazepine was found to be associated with increased risk in all-sites fractures. Subjects without depression were found to have an increased risk of fractures. Diazepam is the only benzodiazepine with increased risk of fractures after adjusting for medications and comorbidities. Hip and spine were particular sites for increased fracture risk, but following adjustment for comorbidities, the associations were found to be insignificant. Conclusion Neither zolpidem nor benzodiazepine was associated with increased risk of all-site fractures in this case cross-over study after adjusting for medications or comorbidities in elderly individuals with insomnia. Clinicians should balance the benefits and risks for prescribing zolpidem or benzodiazepine in the elderly accordingly.en_US
dc.language.isoen_USen_US
dc.titleIs Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwanen_US
dc.typeArticleen_US
dc.identifier.doi10.1371/journal.pone.0146030en_US
dc.identifier.journalPLOS ONEen_US
dc.citation.volume10en_US
dc.citation.issue12en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000367510500121en_US
dc.citation.woscount6en_US
Appears in Collections:Articles


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