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dc.contributor.authorChang, Kuo-Weien_US
dc.contributor.authorChang, Pei-Yuen_US
dc.contributor.authorHuang, Hong-Yuanen_US
dc.contributor.authorLi, Chin-Jungen_US
dc.contributor.authorTien, Chang-Hungen_US
dc.contributor.authorYao, Da-Jengen_US
dc.contributor.authorFan, Shih-Kangen_US
dc.contributor.authorHsu, Wensyangen_US
dc.contributor.authorLiu, Cheng-Hsienen_US
dc.date.accessioned2016-03-28T00:04:23Z-
dc.date.available2016-03-28T00:04:23Z-
dc.date.issued2016-04-01en_US
dc.identifier.issn0925-4005en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.snb.2015.11.004en_US
dc.identifier.urihttp://hdl.handle.net/11536/129618-
dc.description.abstractThe 3D biomimetic microsystem described in this research integrates various functions of the fallopian tube to serve as an in vitro platform for fertilization and embryonic development. This device mimics the in vivo embryo-endometrial stromal cell monolayer coculture to enhance the group culture of embryos and mechanically culture the embryos in a dynamic manner to enhance their development. The microdevice presented here is compared with static culture for embryonic development rate in the presence and absence of epithelial cells. The results suggest that the dynamic biomimetic microsystem enhances the rate of embryo development, providing a culture environment that closely mimics the in vivo microenvironment. This all-in-one biomimetic microsystem has the potential to replace the present embryo culture platforms used for assisting in vitro fertilization. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectBiomimetic microsystemen_US
dc.subjectEmbryoen_US
dc.subjectEndometrial stromal cellen_US
dc.subjectEmbryonic developmenten_US
dc.titleWomb-on-a-chip biomimetic system for improved embryo culture and developmenten_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.snb.2015.11.004en_US
dc.identifier.journalSENSORS AND ACTUATORS B-CHEMICALen_US
dc.citation.volume226en_US
dc.citation.spage218en_US
dc.citation.epage226en_US
dc.contributor.department機械工程學系zh_TW
dc.contributor.departmentDepartment of Mechanical Engineeringen_US
dc.identifier.wosnumberWOS:000368810300029en_US
dc.citation.woscount0en_US
Appears in Collections:Articles