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dc.contributor.authorWan, Ilynnen_US
dc.contributor.authorPokora, Ondrejen_US
dc.contributor.authorChiu, Tzaiwenen_US
dc.contributor.authorLansky, Petren_US
dc.contributor.authorPoon, Paul Waifungen_US
dc.date.accessioned2016-03-28T00:05:42Z-
dc.date.available2016-03-28T00:05:42Z-
dc.date.issued2015-10-01en_US
dc.identifier.issn0303-2647en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.biosystems.2015.06.010en_US
dc.identifier.urihttp://hdl.handle.net/11536/129778-
dc.description.abstractTinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectAuditory evoked potentialen_US
dc.subjectElectrocorticogramen_US
dc.subjectFisher informationen_US
dc.subjectSalicylate-overdoseen_US
dc.subjectTinnitusen_US
dc.subjectRaten_US
dc.titleAltered intensity coding in the salicylate-overdose animal model of tinnitusen_US
dc.typeArticle; Proceedings Paperen_US
dc.identifier.doi10.1016/j.biosystems.2015.06.010en_US
dc.identifier.journalBIOSYSTEMSen_US
dc.citation.volume136en_US
dc.citation.spage113en_US
dc.citation.epage119en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000366535200014en_US
dc.citation.woscount0en_US
Appears in Collections:Conferences Paper