Title: Altered intensity coding in the salicylate-overdose animal model of tinnitus
Authors: Wan, Ilynn
Pokora, Ondrej
Chiu, Tzaiwen
Lansky, Petr
Poon, Paul Waifung
生物科技學系
Department of Biological Science and Technology
Keywords: Auditory evoked potential;Electrocorticogram;Fisher information;Salicylate-overdose;Tinnitus;Rat
Issue Date: 1-Oct-2015
Abstract: Tinnitus is one of the leading disorders of hearing with no effective cure as its pathophysiological mechanisms remain unclear. While the sensitivity to sound is well-known to be affected, exactly how intensity coding per se is altered remains unclear. To address this issue, we used a salicylate-overdose animal model of tinnitus to measure auditory cortical evoked potentials at various stimulus levels, and analyzed on single-trial basis the response strength and its variance for the computation of the lower bound of Fisher information. Based on Fisher information profiles, we compared the precision or efficiency of intensity coding before and after salicylate-treatment. We found that after salicylate treatment, intensity coding was unexpectedly improved, rather than impaired. Also, the improvement varied in a sound-dependent way. The observed changes are likely due to some central compensatory mechanisms that are activated during tinnitus to bring out the full capacity of intensity coding which is expressed only in part under normal conditions. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.biosystems.2015.06.010
http://hdl.handle.net/11536/129778
ISSN: 0303-2647
DOI: 10.1016/j.biosystems.2015.06.010
Journal: BIOSYSTEMS
Volume: 136
Begin Page: 113
End Page: 119
Appears in Collections:Conferences Paper