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dc.contributor.authorLin, Yu-Lingen_US
dc.contributor.authorChen, Chia-Hungen_US
dc.contributor.authorWu, Hsin-Yien_US
dc.contributor.authorTsai, Nu-Manen_US
dc.contributor.authorJian, Ting-Yanen_US
dc.contributor.authorChang, Yuan-Chingen_US
dc.contributor.authorLin, Chi-Hsinen_US
dc.contributor.authorWu, Chih-Hsiungen_US
dc.contributor.authorHsu, Fei-Tingen_US
dc.contributor.authorLeung, Ting Kaien_US
dc.contributor.authorLiao, Kuang-Wenen_US
dc.date.accessioned2019-04-03T06:44:15Z-
dc.date.available2019-04-03T06:44:15Z-
dc.date.issued2016-02-19en_US
dc.identifier.issn1477-3155en_US
dc.identifier.urihttp://dx.doi.org/10.1186/s12951-016-0163-3en_US
dc.identifier.urihttp://hdl.handle.net/11536/132608-
dc.description.abstractBackground: Tamoxifen is currently used for the treatment of both early and advanced estrogen receptor (ER) positive breast cancer in pre- and post-menopausal women. However, using tamoxifen routinely to inhibit endogenous or exogenous estrogen effects is occasionally difficult because of its potential side effects. Objectives: The aim of this study is to design a local drug delivery system to encapsulate tamoxifen for observing their efficacy of skin penetration, drug accumulation and cancer therapy. Methods: A cationic liposome-PEG-PEI complex (LPPC) was used as a carrier for the encapsulation of tamoxifen and forming 'LPPC/TAM' for transdermal release. The cytotoxicity of LPPC/TAM was analyzed by MTT. The skin penetration, tumor growth inhibition and organ damages were measured in xenograft mice following transdermal treatment. Results: LPPC/TAM had an average size less than 270 nm and a zeta-potential of approximately 40 mV. LPPC/TAM displayed dramatically increased the cytotoxic activity in all breast cancer cells, especially in ER-positive breast cancer cells. In vivo, LPPC drug delivery helped the fluorescent dye penetrating across the skim and accumulating rapidly in tumor area. Administration of LPPC/TAM by transdermal route inhibited about 86 % of tumor growth in mice bearing BT474 tumors. This local treatment of LPPC/TAM did not injury skin and any organs. Conclusion: LPPC-delivery system provided a better skin penetration and drug accumulation and therapeutic efficacy. Therefore, LPPC/TAM drug delivery maybe a useful transdermal tool of drugs utilization for breast cancer therapy.en_US
dc.language.isoen_USen_US
dc.subjectLipo-PEG-PEI complexen_US
dc.subjectTamoxifenen_US
dc.subjectTransdermal treatmenten_US
dc.subjectBreast canceren_US
dc.titleInhibition of breast cancer with transdermal tamoxifen-encapsulated lipoplexen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s12951-016-0163-3en_US
dc.identifier.journalJOURNAL OF NANOBIOTECHNOLOGYen_US
dc.citation.volume14en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.department生物資訊研究中心zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.contributor.departmentCenter for Bioinformatics Researchen_US
dc.identifier.wosnumberWOS:000370595900001en_US
dc.citation.woscount10en_US
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