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dc.contributor.authorSkeggs, Andrewen_US
dc.contributor.authorMcKeever, Triciaen_US
dc.contributor.authorDuley, Leliaen_US
dc.contributor.authorMitchell, Eleanoren_US
dc.contributor.authorBradshaw, Lucyen_US
dc.contributor.authorMortimer, Kevinen_US
dc.contributor.authorWalker, Samanthaen_US
dc.contributor.authorParrott, Steveen_US
dc.contributor.authorWilson, Andrewen_US
dc.contributor.authorPavord, Ianen_US
dc.contributor.authorBrightling, Chrisen_US
dc.contributor.authorThomas, Mikeen_US
dc.contributor.authorPrice, Daviden_US
dc.contributor.authorDevereux, Grahamen_US
dc.contributor.authorHiggins, Bernarden_US
dc.contributor.authorHarrison, Timen_US
dc.contributor.authorHaydock, Rebeccaen_US
dc.date.accessioned2019-04-03T06:39:37Z-
dc.date.available2019-04-03T06:39:37Z-
dc.date.issued2016-10-13en_US
dc.identifier.issn1745-6215en_US
dc.identifier.urihttp://dx.doi.org/10.1186/s13063-016-1608-6en_US
dc.identifier.urihttp://hdl.handle.net/11536/132635-
dc.description.abstractBackground: Asthma is one of the commonest chronic diseases in the UK. Acute exacerbations of asthma are unpredictable, disruptive and frightening. They cause considerable morbidity and account for a large component of the health service costs of asthma. The widespread use of an asthma self-management plan, designed to encourage disease monitoring and timely intervention, can reduce exacerbations and is, therefore, recommended for all patients with asthma. Unfortunately, the majority of patients are not provided with such a plan. There are a variety of reasons for this but uncertainty about what to include in the plan when asthma control is deteriorating, but before the need for orally administered corticosteroids, is a contributing factor. The aim of this trial is to determine whether an asthma self-management plan, which includes a temporary quadrupling of the dose of inhaled corticosteroid when asthma control starts to deteriorate, reduces asthma exacerbations requiring orally administered corticosteroids or unscheduled health care consultation for asthma. Methods: A multicentre, pragmatic, randomised trial in adults aged over 16 years with a clinical diagnosis of asthma, treated with a licensed dose of inhaled corticosteroid and at least one exacerbation in the previous 12 months requiring treatment with systemic corticosteroids. Participants will be randomised to either a self-management plan, which includes a temporary (maximum of 14 days) fourfold increase in inhaled corticosteroid or the same plan without an increase in inhaled corticosteroid. Participants will be followed up at 6 and 12 months and will attend the clinic for an additional visit if their asthma control deteriorates. The primary outcome is time to first asthma exacerbation, defined as the need for systemic corticosteroids and/or unscheduled health care consultation for asthma. The estimated sample size is 1800 participants. Discussion: The FAST trial is an independent study that has been prioritised and commissioned by the National Institute for Health Research (NIHR) in the United Kingdom. It will provide high-quality evidence to inform clinical decision-making on the role of an asthma self-management plan, which includes a temporary fourfold increase of inhaled corticosteroid, when asthma control starts to deteriorate. The first participant was randomised on 17th May 2013 and recruitment will close on 31 January 2016 with the last patient last visit taking place in January 2017.en_US
dc.language.isoen_USen_US
dc.subjectAsthmaen_US
dc.subjectExacerbationen_US
dc.subjectSelf-management planen_US
dc.subjectInhaled corticosteroidsen_US
dc.subjectOral corticosteroids Randomised controlled trialen_US
dc.subjectFourfolden_US
dc.subjectProtocolen_US
dc.subjectPrimary careen_US
dc.titleFourFold Asthma Study (FAST): a study protocol for a randomised controlled trial evaluating the clinical cost-effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbationsen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/s13063-016-1608-6en_US
dc.identifier.journalTRIALSen_US
dc.citation.volume17en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department交大名義發表zh_TW
dc.contributor.departmentNational Chiao Tung Universityzh_TW
dc.identifier.wosnumberWOS:000385434800005en_US
dc.citation.woscount2en_US
Appears in Collections:Articles


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