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dc.contributor.authorCheng, Chih-Chiaen_US
dc.contributor.authorLin, I-Hongen_US
dc.contributor.authorChen, Jem-Kunen_US
dc.contributor.authorLiao, Zhi-Shengen_US
dc.contributor.authorHuang, Jyun-Jieen_US
dc.contributor.authorLee, Duu-Jongen_US
dc.contributor.authorXin, Zhongen_US
dc.date.accessioned2017-04-21T06:56:40Z-
dc.date.available2017-04-21T06:56:40Z-
dc.date.issued2016-10en_US
dc.identifier.issn1616-5187en_US
dc.identifier.urihttp://dx.doi.org/10.1002/mabi.201600189en_US
dc.identifier.urihttp://hdl.handle.net/11536/132651-
dc.description.abstractComplementary nucleobase-functionalized polymeric micelles, a combination of adenine-thymine (A-U) base pairs and a blend of hydrophilic-hydrophobic polymer pairs, can be used to construct 3D supramolecular polymer networks; these micelles exhibit excellent self-assembly ability in aqueous solution, rapid pH-responsiveness, high drug loading capacity, and triggerable drug release. In this study, a multi-uracil functionalized poly(epsilon-caprolactone) (U-PCL) and adenine end-capped difunctional oligomeric poly(ethylene glycol) (BA-PEG) are successfully developed and show high affinity and specific recognition in solution owing to dynamically reversible A-U-induced formation of physical cross-links. The U-PCL/BA-PEG blend system produces supramolecular micelles that can be readily adjusted to provide the desired critical micellization concentration, particle size, and stability. Importantly, in vitro release studies show that doxorubicin (DOX)-loaded micelles exhibit excellent DOX-encapsulated stability under physiological conditions. When the pH value of the solution is reduced from 7.4 to 5.0, DOX-loaded micelles can be rapidly triggered to release encapsulated DOX, suggesting these polymeric micelles represent promising candidate pH-responsive nanocarriers for controlled-release drug delivery and pharmaceutical applications.en_US
dc.language.isoen_USen_US
dc.subjectbiocomplementary interactionen_US
dc.subjectcontrolled-release drug deliveryen_US
dc.subjectpH-responsive micelleen_US
dc.subjectself-assemblyen_US
dc.subjectsupramolecular polymeren_US
dc.titleNucleobase-Functionalized Supramolecular Micelles with Tunable Physical Properties for Efficient Controlled Drug Releaseen_US
dc.identifier.doi10.1002/mabi.201600189en_US
dc.identifier.journalMACROMOLECULAR BIOSCIENCEen_US
dc.citation.volume16en_US
dc.citation.issue10en_US
dc.citation.spage1415en_US
dc.citation.epage1421en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000386100700001en_US
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