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dc.contributor.authorZhao, Yeen_US
dc.contributor.authorJiang, Zhaoleien_US
dc.contributor.authorTsai, Wei-Chungen_US
dc.contributor.authorYuan, Yuanen_US
dc.contributor.authorChinda, Kroekkiaten_US
dc.contributor.authorChoi, Eue-Keunen_US
dc.contributor.authorFishbein, Michael C.en_US
dc.contributor.authorLin, Shien-Fongen_US
dc.contributor.authorChen, Peng-Shengen_US
dc.contributor.authorEverett, Thomas H.en_US
dc.date.accessioned2017-04-21T06:55:51Z-
dc.date.available2017-04-21T06:55:51Z-
dc.date.issued2016-10en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.hrthm.2016.07.014en_US
dc.identifier.urihttp://hdl.handle.net/11536/132887-
dc.description.abstractBACKGROUND Simultaneous activation of the stellate ganglion (SG), the ligament of Marshall (LOM), and the ganglionated plexi often precedes the onset of paroxysmal atrial tachyarrhythmia (PAT). OBJECTIVE The purpose of this study was to test the hypothesis that ablation of the LOM and the superior left ganglionated plexi (SLGP) reduces atrial vulnerability and results in remodeling of the SG. METHODS Nerve activity was correlated to PAT and ventricular rate (VR) at baseline, after ablation of the LOM and SLGP, and after atrial fibrillation. Neuronal cell death was assessed with tyrosine hydroxylase and terminal deoxynucleotidyl transferase dUTP nick end label (TUNEL) staining. RESULTS There were 4 2 PAT episodes per day in controls. None were observed in the ablation group, even though SG nerve activity and VR increased from 2.2 mu V (95% confidence interval [CI] 1.2-3.3 mu V) and 80 bpm (95% CI 68-92 bpm) at baseline, to 3.0 mu V (95% CI 2.6-3.4 mu V, P = .046) and 90 bpm (95% CI 75-108 bpm, P = .026) after ablation, and to 3.1 mu V (95% CI 1.7-4.5 mu V, P = .116) and 95 bpm (95% CI 79-110 bpm, P = .075) after atrial fibrillation. There was an increase in tyrosine hydroxylase negative cells in the ablation group and 19.7% (95% CI 8.6%-30.8%) TUN EL-positive staining in both the left and right SG. None were observed in the control group. CONCLUSION LOM and SLGP ablation caused left SG remodeling and cell death. There was reduced correlation of the VR response and PAT to SG nerve activity. These findings support the importance of SLGP and LOM in atrial arrhythmogenesis.en_US
dc.language.isoen_USen_US
dc.subjectAblationen_US
dc.subjectSuperior left ganglion plexien_US
dc.subjectLigament ofen_US
dc.subjectMarshallen_US
dc.subjectAtrial fibrillationen_US
dc.titleGanglionated plexi and ligament of Marshall ablation reduces atrial vulnerability and causes stellate ganglion remodeling in ambulatory dogsen_US
dc.identifier.doi10.1016/j.hrthm.2016.07.014en_US
dc.identifier.journalHEART RHYTHMen_US
dc.citation.volume13en_US
dc.citation.issue10en_US
dc.citation.spage2083en_US
dc.citation.epage2090en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000388273900026en_US
Appears in Collections:Articles