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dc.contributor.authorChen, Chih-Linen_US
dc.contributor.authorChen, Ting-Ruen_US
dc.contributor.authorChiu, Shih-Haoen_US
dc.contributor.authorUrban, Pawel L.en_US
dc.date.accessioned2017-04-21T06:55:26Z-
dc.date.available2017-04-21T06:55:26Z-
dc.date.issued2017-02en_US
dc.identifier.issn0925-4005en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.snb.2016.08.031en_US
dc.identifier.urihttp://hdl.handle.net/11536/132951-
dc.description.abstractChemistry-related procedures often involve a substantial investment of manual work. Automated procedures have been developed to reduce the burden of sample processing and analysis. Here, we demonstrate an automated system for sequential sample processing and delivery to a mass spectrometer. This new platform referred to as RAMSAY-2 incorporates two robotic arms. The arms are guided by several inexpensive, open-source, electronic modules. RAMSAY-2 performs various operations on the samples. Two robotic arms work synchronously to process multiple samples. The system recognizes the delivered samples, aliquots solutions (e.g., substrates of biochemical reactions, diluents), incubates the samples with the reagents, delivers the processed samples to the ion source of the mass spectrometer, and initiates data acquisition. The increased efficiency and versatility are due to implementation of two arms, several microfluidic pumps, fast servos, and the modular design of the control unit. RAMSAY-2 handles multiple sample processing workflows encoded in radio frequency identification tags attached to the samples and can easily be reprogrammed according to the specific requirements of sample processing before mass spectrometric detection. As an example, we demonstrate that RAMSAY-2 can autonomously collect data to evaluate enzymatic activities in enzyme samples supplied by the user. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectAutomated analysisen_US
dc.subjectMass spectrometryen_US
dc.subjectOpen-source electronicsen_US
dc.subjectRoboticsen_US
dc.subjectSample handlingen_US
dc.titleDual robotic arm "production line" mass spectrometry assay guided by multiple Arduino-type microcontrollersen_US
dc.identifier.doi10.1016/j.snb.2016.08.031en_US
dc.identifier.journalSENSORS AND ACTUATORS B-CHEMICALen_US
dc.citation.volume239en_US
dc.citation.spage608en_US
dc.citation.epage616en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000388951300075en_US
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