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dc.contributor.authorChou, Feng-Paien_US
dc.contributor.authorTsai, Chia-Tseen_US
dc.contributor.authorChiou, Ya-Shengen_US
dc.contributor.authorChen, Yi-Juen_US
dc.contributor.authorLi, Meng-Erhen_US
dc.contributor.authorGuo, Ting-Weien_US
dc.contributor.authorLyu, Jason WenJayen_US
dc.contributor.authorChou, Sheng-Haoen_US
dc.contributor.authorWu, Tung-Kungen_US
dc.date.accessioned2017-04-21T06:55:28Z-
dc.date.available2017-04-21T06:55:28Z-
dc.date.issued2017-01en_US
dc.identifier.issn1747-0277en_US
dc.identifier.urihttp://dx.doi.org/10.1111/cbdd.12830en_US
dc.identifier.urihttp://hdl.handle.net/11536/132958-
dc.description.abstractEnzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl--glucosides. Investigation of trans-androsteronyl--glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl--glucosides with useful biological activities.en_US
dc.language.isoen_USen_US
dc.subjectglycosyltransferaseen_US
dc.subjectHelicobacter pylorien_US
dc.subjectMCF-7 breast cancer cellen_US
dc.subjectsteroid -glucosideen_US
dc.subjectsterolen_US
dc.titleAn enzymatic approach to configurationally rare trans-androsteronyl--glucoside and Its potential anticancerapplicationen_US
dc.identifier.doi10.1111/cbdd.12830en_US
dc.identifier.journalCHEMICAL BIOLOGY & DRUG DESIGNen_US
dc.citation.volume89en_US
dc.citation.issue1en_US
dc.citation.spage61en_US
dc.citation.epage66en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000390354100005en_US
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