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dc.contributor.authorChang, Ya-Sianen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.contributor.authorYeh, Kun-Tuen_US
dc.contributor.authorChang, Jan-Gowthen_US
dc.date.accessioned2017-04-21T06:55:43Z-
dc.date.available2017-04-21T06:55:43Z-
dc.date.issued2016-02en_US
dc.identifier.issn0014-4800en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.yexmp.2015.11.026en_US
dc.identifier.urihttp://hdl.handle.net/11536/132974-
dc.description.abstractMany genetic factors play important roles in the development of endometrial cancer. The aim of this study was to investigate genetic alterations in the Taiwanese population with endometrial cancer. DNA was extracted from 10 cases of fresh-frozen endometrial cancer tissue. The exomes of cancer-related genes were captured using the NimbleGen Comprehensive Cancer Panel (578 cancer-related genes) and sequenced using the Illumina Genomic Sequencing Platform. Our results revealed 120 variants in 99 genes, 21 of which were included in the Oncomine Cancer Research Panel used in the National Cancer Institute Match Trial. The 21 genes comprised 8 tumor suppressor candidates (AIM, MSH2, PIK3R1, PTCH1, PTEN, TET2, TP53, and TSC1) and 13 oncogene candidates (ALK, BCL9, CTNNB1, ERBB2, FGFR2, FLT3, HNF1A, KIT, MTOR, PDGFRA, PPP2R1A, PTPN11, and SF3B1). We identified a high frequency of mutations in PTEN (50%) and genes involved in the endometrial cancer-related molecular pathway, which involves the IL-7 signaling pathway (PIK3R1, n = 1; AKT2, n = 1; FOXO1, n = 1). We report the mutational landscape of endometrial cancer in the Taiwanese population. We believe that this study will shed new light on fundamental aspects for understanding the molecular pathogenesis of endometrial cancer and may aid in the development of new targeted therapies. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectEndometrial canceren_US
dc.subjectNext-generation sequencingen_US
dc.subjectPTEN mutationen_US
dc.subjectIL-7 signaling pathwayen_US
dc.titleGenetic alterations in endometrial cancer by targeted next-generation sequencingen_US
dc.identifier.doi10.1016/j.yexmp.2015.11.026en_US
dc.identifier.journalEXPERIMENTAL AND MOLECULAR PATHOLOGYen_US
dc.citation.volume100en_US
dc.citation.issue1en_US
dc.citation.spage8en_US
dc.citation.epage12en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000369879100002en_US
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