標題: Controllable NO release from Cu1.6S nanoparticle decomposition of S-nitrosoglutathiones following photothermal disintegration of polymersomes to elicit cerebral vasodilatory activity
作者: Kao, Po-Tsung
Lee, I-Ju
Liau, Ian
Yeh, Chen-Sheng
交大名義發表
生物科技學系
National Chiao Tung University
Department of Biological Science and Technology
公開日期: 1-一月-2017
摘要: Since the discovery of nitric oxide (NO) as a vasodilator, numerous NO therapies have been attempted to remedy disorders related to pathological vasoconstriction such as coronary artery disease. Despite the advances, clinical applications of NO therapies remain limited mainly because of the low stability of molecular NO donors (and NO molecules), and concerns about the increased oxidative stress and reduced arterial pressure associated with the systemic administration of NO. Here we design a photo-responsive polymersome with nitrosothiols and Cu1.6S nanoparticles in its core and shell, respectively, and demonstrate the photo-triggered release of NO and its vasodilatory activity on zebrafish. Unlike conventional approaches, our design enhances the stability of NO donors and prospectively enables spatiotemporal regulation of NO release, thus minimizing the harmful effects associated with conventional NO therapies. We anticipate that such a strategy will open up new clinical applications of NO and help reveal the complex biological effects of NO in vivo.
URI: http://dx.doi.org/10.1039/c6sc02774a
http://hdl.handle.net/11536/133061
ISSN: 2041-6520
DOI: 10.1039/c6sc02774a
期刊: CHEMICAL SCIENCE
Volume: 8
Issue: 1
起始頁: 291
結束頁: 297
顯示於類別:期刊論文


文件中的檔案:

  1. 4cc2285b757481ad2653687a4ff43dd1.pdf

若為 zip 檔案,請下載檔案解壓縮後,用瀏覽器開啟資料夾中的 index.html 瀏覽全文。