完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Lin, Han-Huei | en_US |
dc.contributor.author | Gutenberg, Angelika | en_US |
dc.contributor.author | Chen, Tzu-Yu | en_US |
dc.contributor.author | Tsai, Nu-Man | en_US |
dc.contributor.author | Lee, Chia-Jung | en_US |
dc.contributor.author | Cheng, Yu-Che | en_US |
dc.contributor.author | Cheng, Wen-Hui | en_US |
dc.contributor.author | Tzou, Ywh-Min | en_US |
dc.contributor.author | Caturegli, Patrizio | en_US |
dc.contributor.author | Tzou, Shey-Cherng | en_US |
dc.date.accessioned | 2019-04-03T06:36:54Z | - |
dc.date.available | 2019-04-03T06:36:54Z | - |
dc.date.issued | 2017-03-06 | en_US |
dc.identifier.issn | 2045-2322 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1038/srep43492 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/133138 | - |
dc.description.abstract | Autoimmune hypophysitis (AH) is a chronic inflammatory disease characterized by infiltration of T and B lymphocytes in the pituitary gland. The mechanisms through which infiltrating lymphocytes cause disease remain unknown. Using a mouse model of AH we assessed whether T lymphocytes undergo activation in the pituitary gland. Infiltrating T cells co-localized with dendritic cells in the pituitary and produced increased levels of interferon-gamma and interleukin-17 upon stimulation in vitro. Assessing proliferation of CD3- and B220-postive lymphocytes by double immunohistochemistry (PCNA-staining) and flow cytometry (BrdU incorporation) revealed that a discrete proportion of infiltrating T cells and B cells underwent proliferation within the pituitary parenchyma. This proliferation persisted into the late disease stage (day 56 post-immunization), indicating the presence of a continuous generation of autoreactive T and B cells within the pituitary gland. T cell proliferation in the pituitary was confirmed in patients affected by autoimmune hypophysitis. In conclusion, we show that pituitary-infiltrating lymphocytes proliferate in situ during AH, providing a previously unknown pathogenic mechanism and new avenues for treatment. | en_US |
dc.language.iso | en_US | en_US |
dc.title | In Situ Activation of Pituitary-Infiltrating T Lymphocytes in Autoimmune Hypophysitis | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1038/srep43492 | en_US |
dc.identifier.journal | SCIENTIFIC REPORTS | en_US |
dc.citation.volume | 7 | en_US |
dc.citation.spage | 0 | en_US |
dc.citation.epage | 0 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 分子醫學與生物工程研究所 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Institute of Molecular Medicine and Bioengineering | en_US |
dc.identifier.wosnumber | WOS:000395428000001 | en_US |
dc.citation.woscount | 3 | en_US |
顯示於類別: | 期刊論文 |