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dc.contributor.authorChinda, Kroekkiaten_US
dc.contributor.authorTsai, Wei-Chungen_US
dc.contributor.authorChan, Yi-Hsinen_US
dc.contributor.authorLin, Andrew Y-Ten_US
dc.contributor.authorPatel, Jheelen_US
dc.contributor.authorZhao, Yeen_US
dc.contributor.authorTan, Alex Y.en_US
dc.contributor.authorShen, Mark J.en_US
dc.contributor.authorLin, Hongboen_US
dc.contributor.authorShen, Changyuen_US
dc.contributor.authorChattipakorn, Niponen_US
dc.contributor.authorRubart-von der Lohe, Michaelen_US
dc.contributor.authorChen, Lan S.en_US
dc.contributor.authorFishbein, Michael C.en_US
dc.contributor.authorLin, Shien-Fongen_US
dc.contributor.authorChen, Zhenhuien_US
dc.contributor.authorChen, Peng-Shengen_US
dc.date.accessioned2017-04-21T06:56:46Z-
dc.date.available2017-04-21T06:56:46Z-
dc.date.issued2016-03en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.hrthm.2015.11.031en_US
dc.identifier.urihttp://hdl.handle.net/11536/133504-
dc.description.abstractBACKGROUND The effects of intermittent open-loop vagal nerve stimulation (VNS) on the ventricular rate (VR) during atrial fibrillation (AF) remain unclear. OBJECTIVE The purpose of this study was to test the hypothesis that VNS damages the stellate ganglion (SG) and improves VR control during persistent AF. METHODS We performed left cervical VNS in ambulatory dogs while recording the left SG nerve activity (SGNA) and vagal nerve activity. Tyrosine hydroxylase (TH) staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining were used to assess neuronal cell death in the SG. RESULTS We induced persistent AF by atrial pacing in 6 dogs, followed by intermittent VNS with short ON-time (14 seconds) and long OFF-time (66 seconds). The integrated SGNA and VR during AF were 4.84 mV . s (95% confidence interval [CI] 3.08-6.60 mV . s) and 142 beats/min (95% CI 116-168 beats/min), respectively. During AF, VNS reduced the integrated SGNA and VR, respectively, to 3.74 mV . s (95% CI 2.27-5.20 mV . s; P =.021) and 115 beats/ min (95% CI 96-134 beats/min; P =.016) during 66-second OFF-time and to 4.07 mV . s (95% CI 2.42-5.72 mV . s; P =.037) and 114 beats/min (95% CI 83-146 beats/min; P =.039) during 3-minute OFF-time. VNS increased the frequencies of prolonged (>3 seconds) pauses during AF. TH staining showed large confluent areas of damage in the left SG, characterized by pyknotic nuclei, reduced TH staining, increased percentage of TH-negative ganglion cells, and positive TUNEL staining. Occasional TUN EL-positive ganglion cells were also observed in the right SG. CONCLUSION VNS damaged the SG, leading to reduced SGNA and better rate control during persistent AF.en_US
dc.language.isoen_USen_US
dc.subjectVagal nerve stimulationen_US
dc.subjectExcitotoxicityen_US
dc.subjectAtrial fibrillationen_US
dc.titleIntermittent left cervical vagal nerve stimulation damages the stellate ganglia and reduces the ventricular rate during sustained atrial fibrillation in ambulatory dogsen_US
dc.identifier.doi10.1016/j.hrthm.2015.11.031en_US
dc.identifier.journalHEART RHYTHMen_US
dc.citation.volume13en_US
dc.citation.issue3en_US
dc.citation.spage771en_US
dc.citation.epage780en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000372367800024en_US
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