標題: | Synthesis of beta-amino esters by regioselective amination of allyl bromides with aryl and alkyl amines |
作者: | Chen, HY Patkar, LN Ueng, SH Lin, CC Lee, ASY 應用化學系 Department of Applied Chemistry |
關鍵字: | beta-amino ester;amination;regioselectivity;alpha-methylene beta-lactam;allyl bromide |
公開日期: | 19-八月-2005 |
摘要: | One of the two possible regioisomers can be exclusively formed by combining a suitable solvent and a specific amount of triethylamine as a base during the amination of allyl bromide 5. The S(N)2' product 7 was produced using dichloromethane as a solvent and triethylamine (7 equiv) as base; S(N)2 product 6 was predominantly generated in hexane with 0.5 equivalents of triethylamine. Furthermore, a new reaction condition for the efficient cyclization of 7 to yield alpha-methylene beta-lactam 8 using Sn[N(TMS)(2)](2) as a reagent, is disclosed. |
URI: | http://dx.doi.org/10.1055/s-2005-871934 http://hdl.handle.net/11536/13394 |
ISSN: | 0936-5214 |
DOI: | 10.1055/s-2005-871934 |
期刊: | SYNLETT |
Volume: | |
Issue: | 13 |
起始頁: | 2035 |
結束頁: | 2038 |
顯示於類別: | 期刊論文 |