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dc.contributor.authorLin, Chih-Mingen_US
dc.contributor.authorChang, Yu-Junen_US
dc.contributor.authorLiu, Chi-Kuangen_US
dc.contributor.authorYu, Cheng-Shengen_US
dc.contributor.authorLu, Henry Horng-Shingen_US
dc.date.accessioned2019-04-03T06:40:15Z-
dc.date.available2019-04-03T06:40:15Z-
dc.date.issued2016-01-01en_US
dc.identifier.issn1178-1998en_US
dc.identifier.urihttp://dx.doi.org/10.2147/CIA.S111637en_US
dc.identifier.urihttp://hdl.handle.net/11536/134042-
dc.description.abstractAge is an important risk factor for stroke, and carotid artery stenosis is the primary cause of first-ever ischemic stroke. Timely intervention with stenting procedures can effectively prevent secondary stroke; however, the impact of stenting on various periprocedural physical functionalities has never been thoroughly investigated. The primary aim of this study was to investigate whether prestenting characteristics were associated with long-term functional outcomes in patients presenting with first-ever ischemic stroke. The secondary aim was to investigate whether patient age was an important factor in outcomes following stenting, measured by the modified Rankin scale (mRS). In total, 144 consecutive patients with first-ever ischemic stroke who underwent carotid artery stenting from January 2010 to November 2014 were included. Clinical data were obtained by review of medical records. The Barthel index (BI) and mRS were used to assess disability before stenting and at 12-month follow-up. In total, 72/144 patients showed improvement (mRS[+]), 71 showed stationary and one showed deterioration in condition (mRS[-]). The prestenting parameters, ratio of cerebral blood volume (1.41 vs 1.2 for mRS[-] vs mRS[+]), BI ( 75 vs 85), and high-sensitivity C-reactive protein (hsCRP 5.0 vs 3.99), differed significantly between the two outcome groups (P<0.05). The internal carotid artery/common carotid artery ratio (P=0.011), BI (P=0.019), ipsilateral internal carotid artery resistance index (P=0.003), and HbA1c (P=0.039) were all factors significantly associated with patient age group. There was no significant association between age and poststenting outcome measured by mRS with 57% of patients in the >= 75 years age group showing mRS(-) and 43% showing mRS(+) (P=0.371). Our findings indicate that in our elderly patient series, carotid artery stenting may benefit a significant proportion of carotid stenotic patients regardless of age. Ratio of cerebral blood volume, BI, and admission hsCRP could serve as important predictors of mRS improvement and may facilitate differentiation of patients at baseline.en_US
dc.language.isoen_USen_US
dc.subjectmodified Rankin scaleen_US
dc.subjectresistance indexen_US
dc.subjectBarthel indexen_US
dc.subjectcommon carotid arteryen_US
dc.subjectcerebral blood volume ratioen_US
dc.titleFirst-ever ischemic stroke in elderly patients: predictors of functional outcome following carotid artery stentingen_US
dc.typeArticleen_US
dc.identifier.doi10.2147/CIA.S111637en_US
dc.identifier.journalCLINICAL INTERVENTIONS IN AGINGen_US
dc.citation.volume11en_US
dc.citation.spage985en_US
dc.citation.epage995en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department統計學研究所zh_TW
dc.contributor.department大數據研究中心zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitute of Statisticsen_US
dc.contributor.departmentBig Data Res Ctren_US
dc.identifier.wosnumberWOS:000380263400001en_US
dc.citation.woscount1en_US
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