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dc.contributor.authorChen, Mien-Chengen_US
dc.contributor.authorChang, Tzu-Haoen_US
dc.contributor.authorChang, Jen-Pingen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.contributor.authorHo, Wan-Chunen_US
dc.contributor.authorLin, Yu-Shengen_US
dc.contributor.authorPan, Kuo-Lien_US
dc.contributor.authorLiu, Wen-Haoen_US
dc.contributor.authorHuang, Yao-Kuangen_US
dc.date.accessioned2017-04-21T06:55:16Z-
dc.date.available2017-04-21T06:55:16Z-
dc.date.issued2016-11-01en_US
dc.identifier.issn0167-5273en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.ijcard.2016.07.179en_US
dc.identifier.urihttp://hdl.handle.net/11536/134192-
dc.description.abstractBackground: MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain unexplored. Methods: This case-control study enrolled 32 MR patients with heart failure, 16 asymptomatic MR patients, and 12 control subjects without heart failure. We used next generation sequencing to study the gene expression profiles in the sera, and quantitative RT-PCR to study serum and tissue miRs in the left atria. Results: Next generation sequencing analysis and enrichment analysis showed that 25 miRs were differentially expressed in the sera of MR patients with heart failure compared to control subjects. The circulating miR-148b-3p (p = 0.002) and miR-409-3p (p = 0.010) were significantly down-regulated in the MR patients with heart failure compared to control subjects. However, only circulation miR-148b-3p was significantly down-regulated in the MR patients without heart failure compared to control subjects (p = 0.009). The tissue miR-409-3p was significantly down-regulated in the MR patients with heart failure compared to 3 purchased normal controls (p = 0.041). Notably, the tissue RASGRP3 mRNA, target gene of miR-409-3p, was significantly upregulated in the MR patients with heart failure compared to normal controls (p = 0.010). The tissue FRY (p = 0.010) and GADD45A (p = 0.010) mRNAs, target genes of miR-148b-3p, were significantly up-regulated in the MR patients with heart failure compared to normal controls. Conclusions: Circulating miR-148b-3p might serve as biomarker for future development of heart failure and miR-409-3p might serve as biomarker for incident heart failure in MR patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectAtriumen_US
dc.subjectGenesen_US
dc.subjectHeart failureen_US
dc.subjectMitral regurgitationen_US
dc.titleCirculating miR-148b-3p and miR-409-3p as biomarkers for heart failure in patients with mitral regurgitationen_US
dc.identifier.doi10.1016/j.ijcard.2016.07.179en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF CARDIOLOGYen_US
dc.citation.volume222en_US
dc.citation.spage148en_US
dc.citation.epage154en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000384698300028en_US
Appears in Collections:Articles