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dc.contributor.authorChiu, T. -W.en_US
dc.contributor.authorLiu, Y. -J.en_US
dc.contributor.authorChang, H. -C.en_US
dc.contributor.authorLee, Y. -H.en_US
dc.contributor.authorLee, J. -C.en_US
dc.contributor.authorHsu, K.en_US
dc.contributor.authorWang, C. -W.en_US
dc.contributor.authorYang, J. -M.en_US
dc.contributor.authorHsu, H. -H.en_US
dc.contributor.authorJuan, C. -J.en_US
dc.date.accessioned2017-04-21T06:55:14Z-
dc.date.available2017-04-21T06:55:14Z-
dc.date.issued2016-10en_US
dc.identifier.issn0195-6108en_US
dc.identifier.urihttp://dx.doi.org/10.3174/ajnr.A4852en_US
dc.identifier.urihttp://hdl.handle.net/11536/134203-
dc.description.abstractBACKGROUND AND PURPOSE: Parotid glands secrete and empty saliva into the oral cavity rapidly after gustatory stimulation. However, the role of the temporal resolution of DWI in investigating parotid gland function remains uncertain. Our aim was to design a high-temporal-resolution echo-planar DWI pulse sequence and to evaluate the instantaneous MR perfusion responses of the parotid glands to gustatory stimulation. MATERIALS AND METHODS: This prospective study enrolled 21 healthy volunteers (M/F = 2:1; mean age, 45.2 12.9 years). All participants underwent echo-planar DWI (total scan time, 304 seconds; temporal resolution, 4 s/scan) on a 1.5T MR imaging scanner. T2WI (b = 0 s/mm(2)) and DWI (b = 200 s/mm(2)) were qualitatively assessed. Signal intensity of the parotid glands on T2WI, DWI, and ADC was quantitatively analyzed. One-way ANOVA with post hoc group comparisons with Bonferroni correction was used for statistical analysis. P < .05 was statistically significant. RESULTS: Almost perfect interobserver agreement was achieved ( 0.656). The parotid glands had magnetic susceptibility artifacts in 14.3% (3 of 21) of volunteers during swallowing on DWI but were free from perceptible artifacts at the baseline and at the end of scans on all images. Increased ADC and reduced signal intensity of the parotid glands on T2WI and DWI occurred immediately after oral administration of lemon juice. Maximal signal change of ADC (24.8% +/- 10.8%) was significantly higher than that of T2WI (-10.1% +/- 5.2%, P < .001). The recovery ratio of ADC (100.71% +/- 42.34%) was also significantly higher than that of T2WI (22.36% +/- 15.54%, P < .001). CONCLUSIONS: Instantaneous parotid perfusion responses to gustatory stimulation can be quantified by ADC by using high-temporal-resolution echo-planar DWI.en_US
dc.language.isoen_USen_US
dc.titleEvaluating Instantaneous Perfusion Responses of Parotid Glands to Gustatory Stimulation Using High-Temporal-Resolution Echo-Planar Diffusion-Weighted Imagingen_US
dc.identifier.doi10.3174/ajnr.A4852en_US
dc.identifier.journalAMERICAN JOURNAL OF NEURORADIOLOGYen_US
dc.citation.volume37en_US
dc.citation.issue10en_US
dc.citation.spage1909en_US
dc.citation.epage1915en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000383984600029en_US
Appears in Collections:Articles