完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kuo, Yen-Ling | en_US |
dc.contributor.author | Wang, Sin-Ge | en_US |
dc.contributor.author | Wu, Ching-Yi | en_US |
dc.contributor.author | Lee, Kai-Chieh | en_US |
dc.contributor.author | Jao, Chan-Jung | en_US |
dc.contributor.author | Chou, Shiu-Huey | en_US |
dc.contributor.author | Chen, Yu-Chie | en_US |
dc.date.accessioned | 2017-04-21T06:55:15Z | - |
dc.date.available | 2017-04-21T06:55:15Z | - |
dc.date.issued | 2016-10 | en_US |
dc.identifier.issn | 1743-5889 | en_US |
dc.identifier.uri | http://dx.doi.org/10.2217/nnm-2016-0232 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/134207 | - |
dc.description.abstract | Aim: Medical treatments for bacterial-infections have become challenging because of the emergence of antibiotic-resistant bacterial strains. Thus, new therapeutics and antibiotics must be developed. Materials & methods: Arginine and tryptophan can target negatively-charged bacteria and penetrate bacterial cell membrane, respectively. Synthetic-peptides containing arginine, tryptophan and cysteine termini, in other words, (DVFLG) 2 REEW 4 C and (DVFLG) 2 REEW 2 C, as starting materials were mixed with aqueous tetrachloroauric acid to generate peptide-immobilized gold nanoparticles (i.e., [DVFLG] 2 REEW 4 C-AuNPs and [DVFLG] 2 REEW 2 C-AuNPs) through one-pot reactions. Results & discussion: The peptide immobilized AuNPs exhibit targeting capacity and antibacterial activity. Furthermore, (DVFLG) 2 REEW 4 C-AuNPs immobilized with a higher number of tryptophan molecules possess more effective antibacterial capacity than (DVFLG) 2 REEW 2 C-AuNPs. Nevertheless, they are not harmful for animal cells. The feasibility of using the peptide-AuNPs to inhibit the cell growth of bacterium-infected macrophages was demonstrated. Conclusion: These results suggested that the proposed antibacterial AuNPs are effective antibacterial agents for Staphylococci, Enterococci and antibiotic-resistant bacterial strains. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | antibacterial peptides | en_US |
dc.subject | antibiotics | en_US |
dc.subject | antibiotic-resistant bacteria | en_US |
dc.subject | Au NPs | en_US |
dc.subject | Enterococcus faecalis | en_US |
dc.subject | Enterococcus faecium | en_US |
dc.subject | macrophages | en_US |
dc.subject | MRSA | en_US |
dc.subject | Staphylococcus aureus | en_US |
dc.subject | VRE | en_US |
dc.title | Functional gold nanoparticle-based antibacterial agents for nosocomial and antibiotic-resistant bacteria | en_US |
dc.identifier.doi | 10.2217/nnm-2016-0232 | en_US |
dc.identifier.journal | NANOMEDICINE | en_US |
dc.citation.volume | 11 | en_US |
dc.citation.issue | 19 | en_US |
dc.citation.spage | 2497 | en_US |
dc.citation.epage | 2510 | en_US |
dc.contributor.department | 應用化學系 | zh_TW |
dc.contributor.department | Department of Applied Chemistry | en_US |
dc.identifier.wosnumber | WOS:000384221100003 | en_US |
顯示於類別: | 期刊論文 |