標題: | Effect of Peptide Sequences on Supramolecular Interactions of Naphthaleneimide/Tripeptide Conjugates |
作者: | Yeh, Mei-Yu Huang, Ching-Ting Lai, Tsung-Sheng Chen, Fang-Yi Chu, Nien-Tzu Tseng, Dion Tzu-Huan Hung, Shih-Chieh Lin, Hsin-Chieh 材料科學與工程學系 Department of Materials Science and Engineering |
公開日期: | 2-八月-2016 |
摘要: | In this study, we reported a significant difference in the supramolecular hydrogelation of newly discovered NI-GFF (NI-Gly-L-Phe-L-Phe) and NI-FFG (NI-L-Phe-L-Phe-Gly) on the basis of their phase diagrams. With a small difference in the peptide chain between NI-GFF and NI-FFG, we observed a significant difference in their self-assembly properties; NI-GFF formed a stable gel at neutral pH, whereas NI-FFG did not, under the same conditions. From spectroscopic and computational studies, intermolecular pi-pi interactions and extended hydrogen bonding interactions might reinforce the intermolecular interactions of NI-GFF, which may facilitate the formation of the self-assembled nanostructures and the hydrogel. In addition, the aggregation-induced emission (AIE)-active NI-GFF reveals relatively good biocompatibility compared with that of NI-FFG for two commonly used cell lines, suggesting that it is a promising candidate for use as a supramolecular material in biomedical applications. Our results highlight the importance of tripeptide sequences in a self-assembling hydrogel system. |
URI: | http://dx.doi.org/10.1021/acs.langmuir.6b01809 http://hdl.handle.net/11536/134280 |
ISSN: | 0743-7463 |
DOI: | 10.1021/acs.langmuir.6b01809 |
期刊: | LANGMUIR |
Volume: | 32 |
Issue: | 30 |
起始頁: | 7630 |
結束頁: | 7638 |
顯示於類別: | 期刊論文 |