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dc.contributor.authorLai, Wei-Anen_US
dc.contributor.authorLin, Chih-Hengen_US
dc.contributor.authorYang, Yuh-Shyongen_US
dc.contributor.authorLu, Michael S. -C.en_US
dc.date.accessioned2017-04-21T06:49:54Z-
dc.date.available2017-04-21T06:49:54Z-
dc.date.issued2012en_US
dc.identifier.isbn978-1-4673-0325-5en_US
dc.identifier.issn1084-6999en_US
dc.identifier.urihttp://hdl.handle.net/11536/135478-
dc.description.abstractThis work presents miniaturized CMOS (complementary metal oxide semiconductor) impedimetric sensors for detection of avian influenza virus (AIV) in the femto-molar level. The sensing resolution is significantly enhanced owing to monolithic sensor integration to reduce the parasitic effect and the use of sub-mu m interdigitated microelectrodes to promote signal coupling efficiency. The 4x4 sensor array contains four electrode designs of different sizes. Capacitance changes associated with surface modification, functionalization, and DNA hybridization were extracted from measured frequency responses based on an equivalent circuit. Hybridization of AIV H5 capture and target DNA produced a percentage capacitance change of -12.8+/-3% among the four designs for target DNA concentrations from 1 fM to 10 fM, while capacitance increases were observed for non-specific binding of the H5 and H7 DNA probes.en_US
dc.language.isoen_USen_US
dc.titleULTRASENSITIVE DETECTION OF AVIAN INFLUENZA VIRUS BY USING CMOS IMPEDIMETRIC SENSOR ARRAYSen_US
dc.typeProceedings Paperen_US
dc.identifier.journal2012 IEEE 25TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS)en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000312912800225en_US
dc.citation.woscount0en_US
Appears in Collections:Conferences Paper