标题: ULTRASENSITIVE DETECTION OF AVIAN INFLUENZA VIRUS BY USING CMOS IMPEDIMETRIC SENSOR ARRAYS
作者: Lai, Wei-An
Lin, Chih-Heng
Yang, Yuh-Shyong
Lu, Michael S. -C.
生物科技学系
Department of Biological Science and Technology
公开日期: 2012
摘要: This work presents miniaturized CMOS (complementary metal oxide semiconductor) impedimetric sensors for detection of avian influenza virus (AIV) in the femto-molar level. The sensing resolution is significantly enhanced owing to monolithic sensor integration to reduce the parasitic effect and the use of sub-mu m interdigitated microelectrodes to promote signal coupling efficiency. The 4x4 sensor array contains four electrode designs of different sizes. Capacitance changes associated with surface modification, functionalization, and DNA hybridization were extracted from measured frequency responses based on an equivalent circuit. Hybridization of AIV H5 capture and target DNA produced a percentage capacitance change of -12.8+/-3% among the four designs for target DNA concentrations from 1 fM to 10 fM, while capacitance increases were observed for non-specific binding of the H5 and H7 DNA probes.
URI: http://hdl.handle.net/11536/135478
ISBN: 978-1-4673-0325-5
ISSN: 1084-6999
期刊: 2012 IEEE 25TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS)
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