Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes

標題:	Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes
作者:	Fan, GT Pan, YS Lu, KC Cheng, YP Lin, WC Lin, S Lin, CH Wong, CH Fang, JM Lin, CC 應用化學系 Department of Applied Chemistry
關鍵字:	phytosphingosine;alpha-galactosyl ceramide;immuno stimulator;glycolipid
公開日期:	14-二月-2005
摘要:	Phytosphingosine and its short-chain analog were efficiently synthesized with 19% overall yield in 10 steps, respectively, starting from an inexpensive D-lyxose. Galactosyl donors of sulfide and phosphite types bearing benzoyl protecting groups of 4- and 6OH underwent glycosylation in excellent alpha-anomeric selectivity. A variety of alpha-galactosyl, fucosyl and glucosyl ceramides and serine-type lipids were prepared, and their activities involved in the proliferation of mouse splenocytes and the expression of cytokines were elucidated. Besides alpha-galactosyl ceramides, a galactosyl serine-type lipid also exhibited substantial effect on the expression of cytokines IFN-gamma and IL-4. (C) 2004 Elsevier Ltd. All rights reserved.
URI:	http://dx.doi.org/10.1016/j.tet.2004.12.027 http://hdl.handle.net/11536/14003
ISSN:	0040-4020
DOI:	10.1016/j.tet.2004.12.027
期刊:	TETRAHEDRON
Volume:	61
Issue:	7
起始頁:	1855
結束頁:	1862
顯示於類別：	期刊論文

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