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dc.contributor.authorWu, Chih-Jenen_US
dc.contributor.authorChen, Cheng-Yien_US
dc.contributor.authorLai, Thung-S.en_US
dc.contributor.authorWu, Pei-Chenen_US
dc.contributor.authorChuang, Chih-Kuangen_US
dc.contributor.authorSun, Fang-Juen_US
dc.contributor.authorLiu, Hsuan-Liangen_US
dc.contributor.authorChen, Han-Hsiangen_US
dc.contributor.authorYeh, Hung-I.en_US
dc.contributor.authorLin, Chih-Shengen_US
dc.contributor.authorLin, Cheng-Juien_US
dc.date.accessioned2018-08-21T05:52:44Z-
dc.date.available2018-08-21T05:52:44Z-
dc.date.issued2017-10-10en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://dx.doi.org/10.18632/oncotarget.18789en_US
dc.identifier.urihttp://hdl.handle.net/11536/143907-
dc.description.abstractRenal anemia is a common complication in patients with advanced chronic kidney disease. In vitro studies have shown that indoxyl sulfate decreases erythropoietin production. Whether this effect is seen in vivo remains unclear. Our goal was to explore the role of indoxyl sulfate in renal anemia. We found serum indoxyl sulfate levels are significantly and negatively associated with erythropoietin levels in human. A multiple stepwise linear regression analyses after adjustment for other independent parameters revealed that free indoxyl sulfate, and total indoxyl sulfate were significantly associated with erythropoietin levels. In animal studies, erythropoietin gene and protein expression were markedly inhibited in rats with chronic kidney disease; however, this effect was significantly reversed by lowering serum indoxyl sulfate with AST-120. Indoxyl sulfate may also inhibit erythropoietin expression in animal models with chronic kidney disease. These findings further support the role of indoxyl sulfate in the development of renal anemia.en_US
dc.language.isoen_USen_US
dc.subjectindoxyl sulfateen_US
dc.subjectchronic kidney diseaseen_US
dc.subjecterythropoietinen_US
dc.subjectrenal anemiaen_US
dc.titleThe role of indoxyl sulfate in renal anemia in patients with chronic kidney diseaseen_US
dc.typeArticleen_US
dc.identifier.doi10.18632/oncotarget.18789en_US
dc.identifier.journalONCOTARGETen_US
dc.citation.volume8en_US
dc.citation.spage83030en_US
dc.citation.epage83037en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000412683900113en_US
Appears in Collections:Articles