完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.author | Yuan, Yuan | en_US |
dc.contributor.author | Hassel, Jonathan L. | en_US |
dc.contributor.author | Doytchinova, Anisiia | en_US |
dc.contributor.author | Adams, David | en_US |
dc.contributor.author | Wright, Keith C. | en_US |
dc.contributor.author | Meshberger, Chad | en_US |
dc.contributor.author | Chen, Lan S. | en_US |
dc.contributor.author | Guerra, Maria P. | en_US |
dc.contributor.author | Shen, Changyu | en_US |
dc.contributor.author | Lin, Shien-Fong | en_US |
dc.contributor.author | Everett, Thomas H. | en_US |
dc.contributor.author | Salanova, Vicenta | en_US |
dc.contributor.author | Chen, Peng-Sheng | en_US |
dc.date.accessioned | 2018-08-21T05:53:02Z | - |
dc.date.available | 2018-08-21T05:53:02Z | - |
dc.date.issued | 2017-12-01 | en_US |
dc.identifier.issn | 1547-5271 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1016/j.hrthm.2017.07.035 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/144185 | - |
dc.description.abstract | BACKGROUND We recently reported that skin sympathetic nerve activity (SKNA) can be used to estimate sympathetic tone in humans. In animal models, vagal nerve stimulation (VNS) can damage the stellate ganglion, reduce stellate ganglion nerve activity, and suppress cardiac arrhythmia. Whether VNS can suppress sympathetic tone in humans remains unclear. OBJECTIVE The purpose of this study was to test the hypothesis that VNS suppresses SKNA in patients with drug-resistant epilepsy. METHODS ECG patch electrodes were used to continuously record SKNA in 26 patients with drug-resistant epilepsy who were admitted for video electroencephalographic monitoring. Among them, 6 (2 men, age 40 +/- 11 years) were previously treated with VNS and 20 (7 men, age 37 +/- 8 years) were not. The signals from ECG leads I and II were filtered to detect SKNA. RESULTS VNS had an on-time of 30 seconds and off-time of 158672 seconds, with output of 1.9260.42 mA at 24.17 +/- 2.01 Hz. Average SKNA during VNS off-time was 1.06 mV (95% confidence interval [CI] 0.93-1.18) in lead I and 1.13 mV (95% CI 0.99-1.27) in lead II, which was significantly lower than 1.38 mV (95% CI 1.01-1.75; P = .036) and 1.38 mV (95% CI 0.98-1.78; P = .035) in the control group, respectively. Heart rate was 65 bpm (95% CI 59-71) in the VNS group, which was significantly lower than 77 bpm (95% CI 71-83) in the control group. CONCLUSION Patients with VNS had significantly lower SKNA than those without VNS. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Autonomic nervous system | en_US |
dc.subject | Neuromodulation | en_US |
dc.subject | Sudden unexpected death in epilepsy | en_US |
dc.title | Left cervical vagal nerve stimulation reduces skin sympathetic nerve activity in patients with drug resistant epilepsy | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.hrthm.2017.07.035 | en_US |
dc.identifier.journal | HEART RHYTHM | en_US |
dc.citation.volume | 14 | en_US |
dc.citation.spage | 1771 | en_US |
dc.citation.epage | 1778 | en_US |
dc.contributor.department | 分子醫學與生物工程研究所 | zh_TW |
dc.contributor.department | Institute of Molecular Medicine and Bioengineering | en_US |
dc.identifier.wosnumber | WOS:000417131600008 | en_US |
顯示於類別: | 期刊論文 |