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dc.contributor.authorLee, Kuang-Lien_US
dc.contributor.authorHsu, Hsuan-Yehen_US
dc.contributor.authorYou, Meng-Linen_US
dc.contributor.authorChang, Chia-Chunen_US
dc.contributor.authorPan, Ming-Yangen_US
dc.contributor.authorShi, Xuen_US
dc.contributor.authorUeno, Koseien_US
dc.contributor.authorMisawa, Hiroakien_US
dc.contributor.authorWei, Pei-Kuenen_US
dc.date.accessioned2019-04-03T06:36:29Z-
dc.date.available2019-04-03T06:36:29Z-
dc.date.issued2017-03-08en_US
dc.identifier.issn2045-2322en_US
dc.identifier.urihttp://dx.doi.org/10.1038/srep44104en_US
dc.identifier.urihttp://hdl.handle.net/11536/144287-
dc.description.abstractMetallic nanostructure-based surface plasmon sensors are capable of real-time, label-free, and multiplexed detections for chemical and biomedical applications. Recently, the studies of aluminum-based biosensors have attracted a large attention because aluminum is a more cost-effective metal and relatively stable. However, the intrinsic properties of aluminum, having a large imaginary part of the dielectric function and a longer evanescent length, limit its sensing capability. Here we show that capped aluminum nanoslits fabricated on plastic films using hot embossing lithography can provide tailorable Fano resonances. Changing height of nanostructures and deposited metal film thickness modulated the transmission spectrum, which varied from Wood's anomaly-dominant resonance, asymmetric Fano profile to surface plasmon-dominant resonance. For biolayer detections, the maximum surface sensitivity occurred at the dip of asymmetric Fano profile. The optimal Fano factor was close to -1.3. The wavelength and intensity sensitivities for surface thickness were up to 2.58 nm/nm and 90%/nm, respectively. The limit of detection (LOD) of thickness reached 0.018 nm. We attributed the enhanced surface sensitivity for capped aluminum nanoslits to a reduced evanescent length and sharp slope of the asymmetric Fano profile. The protein-protein interaction experiments verified the high sensitivity of capped nanostructures. The LOD was down to 236 fg/mL.en_US
dc.language.isoen_USen_US
dc.titleHighly Sensitive Aluminum-Based Biosensors using Tailorable Fano Resonances in Capped Nanostructuresen_US
dc.typeArticleen_US
dc.identifier.doi10.1038/srep44104en_US
dc.identifier.journalSCIENTIFIC REPORTSen_US
dc.citation.volume7en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.department應用化學系分子科學碩博班zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.contributor.departmentInstitute of Molecular scienceen_US
dc.identifier.wosnumberWOS:000395732600001en_US
dc.citation.woscount14en_US
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