標題: Droplet Size-Aware and Error-Correcting Sample Preparation Using Micro-Electrode-Dot-Array Digital Microfluidic Biochips
作者: Li, Zipeng
Lai, Kelvin Yi-Tse
Chakrabarty, Krishnendu
Ho, Tsung-Yi
Lee, Chen-Yi
電子工程學系及電子研究所
Department of Electronics Engineering and Institute of Electronics
關鍵字: Digital mirofluidics;micro-electrode-dot-array;sample preparation;optimization algorithm;error recovery
公開日期: 1-Dec-2017
摘要: Sample preparation in digital microfluidics refers to the generation of droplets with target concentrations for on-chip biochemical applications. In recent years, digital microfluidic biochips (DMFBs) have been adopted as a platform for sample preparation. However, there remain two major problems associated with sample preparation on a conventional DMFB. First, only a (1: 1) mixing/splitting model can be used, leading to an increase in the number of fluidic operations required for sample preparation. Second, only a limited number of sensors can be integrated on a conventional DMFB; as a result, the latency for error detection during sample preparation is significant. To overcome these drawbacks, we adopt a next generation DMFB platform, referred to as micro-electrode-dot-array (MEDA), for sample preparation. We propose the first sample-preparation method that exploits the MEDA-specific advantages of fine-grained control of droplet sizes and real-time droplet sensing. Experimental demonstration using a fabricated MEDA biochip and simulation results highlight the effectiveness of the proposed sample-preparation method.
URI: http://dx.doi.org/10.1109/TBCAS.2017.2742548
http://hdl.handle.net/11536/144328
ISSN: 1932-4545
DOI: 10.1109/TBCAS.2017.2742548
期刊: IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
Volume: 11
起始頁: 1380
結束頁: 1391
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