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dc.contributor.authorChen, Cheng-Yien_US
dc.contributor.authorLin, Cheng-Juien_US
dc.contributor.authorLin, Chih-Shengen_US
dc.contributor.authorSun, Fang-Juen_US
dc.contributor.authorPan, Chi-Fengen_US
dc.contributor.authorChen, Han-Hsiangen_US
dc.contributor.authorWu, Chih-Jenen_US
dc.date.accessioned2018-08-21T05:53:10Z-
dc.date.available2018-08-21T05:53:10Z-
dc.date.issued2018-01-05en_US
dc.identifier.issn1949-2553en_US
dc.identifier.urihttp://dx.doi.org/10.18632/oncotarget.23368en_US
dc.identifier.urihttp://hdl.handle.net/11536/144344-
dc.description.abstractBackground: Chronic kidney disease (CKD) in cirrhosis is one of the dreaded complications associated with a steep rise in mortality and morbidity, including diabetes. There are limited data on the prevalence of CKD and the association with diabetes in outpatients with cirrhosis. Methodology: This is a cross-sectional study of 7,440 adult liver cirrhosis patients enrolled from August 2001 to April 2010 in a medical center. Case control matching by age and sex with 1,967 pairs, and conditional logistic regression for odds of diabetes was analyzed using adjusted model. Results: CKD was present in 46.0%, 45.7% and 45.6% of the study population using the MDRD-6, CKD-EPI and MDRD-4 estimated glomerular filtration rate (eGFR) equations, respectively. Using a conditional logistic regression model after adjusting for other risk factors, odds for diabetes increased significantly compared with non-CKD in CKD stage 3 to 5 (stage 3 similar to 5) based on MDRD-6-adjusted model, ORs were: stage 3 similar to 5, 2.34 (95% CI, 1.78-3.01); MDRD-4-adjusted model, ORs were: stage 3 similar to 5, 8.51 (95% CI, 5.63-11.4); CKD-EPI-adjusted model, ORs were: stage 3 similar to 5, 8.61 (95% CI, 5.13-13.9). Conclusion: In cirrhosis patients, prevalence of diabetes was higher in patients with advanced stage of CKD. For patients with cirrhosis, patients with CKD stages 3 similar to 5 defined by MDRD-4, MDRD-6, and CKD-EPI eGFR equations had increased risk for diabetes. More severe cirrhosis, indicated by the Child-Turcott-Pugh classification was also accompanied by an increased risk for diabetes.en_US
dc.language.isoen_USen_US
dc.subjectliver cirrhosisen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectdiabetes mellitusen_US
dc.subjectestimated glomerular filtration rateen_US
dc.subjectMELD scoreen_US
dc.titleThe prevalence and association of chronic kidney disease and diabetes in liver cirrhosis using different estimated glomerular filtration rate equationen_US
dc.typeArticleen_US
dc.identifier.doi10.18632/oncotarget.23368en_US
dc.identifier.journalONCOTARGETen_US
dc.citation.volume9en_US
dc.citation.spage2236en_US
dc.citation.epage2248en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000419623200060en_US
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