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dc.contributor.authorShellaiah, Muthaiahen_US
dc.contributor.authorSimon, Turibiusen_US
dc.contributor.authorVenkatesan, Parthibanen_US
dc.contributor.authorSun, Kien Wenen_US
dc.contributor.authorKo, Fu-Hsiangen_US
dc.contributor.authorWu, Shu-Paoen_US
dc.date.accessioned2018-08-21T05:53:11Z-
dc.date.available2018-08-21T05:53:11Z-
dc.date.issued2018-01-01en_US
dc.identifier.issn0026-3672en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s00604-017-2611-7en_US
dc.identifier.urihttp://hdl.handle.net/11536/144371-
dc.description.abstractNanodiamonds were modified such that they carry thiol groups (ND-thiol). Gold nanoparticles were reacted with ND-thiol to obtain a highly stable conjugate of the type ND@AuNPs. Both ND-thiol and the ND@AuNPs were characterized by SEM, TEM, AFM, DLS, zeta potential, XPS, XRD, UV-Vis, Raman, FTIR and cytotoxicity studies. Their biocompatibility was confirmed via an MTT assay with HeLa cells. At a pH value of 6, the ND@AuNPs represent a colorimetric probe that can be used to selectively detect the illegally used beta-adrenergic drug clenbuterol (CLB) and the pollutant chromium(III). Detection can be performed visually by monitoring the color change from wine red to purple blue, or by colorimetric measurement of the so-called SPR peaks at 651 and 710 nm. The color changes are due to aggregation, and this is confirmed by TEM and DLS data. The involvement of surface functional groups that assist in analyte recognition was verified by FTIR. The detection limits are 0.49 nM for CLB, and 0.37 nM for Cr(III). The ND@AuNPs were successfully applied to the determination of Cr(III) and CLB in spiked human urine samples. Notably, the low interference by other ions in the detection of Cr(III) in tap and lake water is confirmed by ICP-MS analyses.en_US
dc.language.isoen_USen_US
dc.subjectGold nanoparticlesen_US
dc.subjectNanocompositeen_US
dc.subjectbeta-Adrenergic drug assayen_US
dc.subjectChromium(III) recognitionen_US
dc.subjectpH effective sensoren_US
dc.subjectSurface plasmon resonanceen_US
dc.subjectSub-nanomolar detectionen_US
dc.subjectUrine analysisen_US
dc.subjectWater analysisen_US
dc.titleNanodiamonds conjugated to gold nanoparticles for colorimetric detection of clenbuterol and chromium(III) in urineen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00604-017-2611-7en_US
dc.identifier.journalMICROCHIMICA ACTAen_US
dc.citation.volume185en_US
dc.contributor.department材料科學與工程學系zh_TW
dc.contributor.department應用化學系zh_TW
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.departmentDepartment of Materials Science and Engineeringen_US
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.identifier.wosnumberWOS:000422691200006en_US
Appears in Collections:Articles