標題: Microwave-Assisted Synthesis of Benzimidazole-Linked Indoline and Indole Hybrids from C-2 Linked (o-Aminobenzyl)benzimidazoles
作者: Lee, Yun-Ta
Chiu, Feng-Yu
Barve, Indrajeet J.
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: benzimidazole-linked indoles;benzimidazole-linked indolines;indoline synthesis;pyrroloindolebenzimidazole-carboxylates;unconventional Pictet-Spengler reaction
公開日期: 1-Feb-2018
摘要: An efficient and novel synthesis of benzimidazole-linked indoline hybrids via an unconventional Pictet-Spengler-type condensation of C-2 linked (o-aminobenzyl) benzimidazoles with aldehydes and ketones under microwave irradiation has been explored. The key condensation step consists of acid-catalyzed imine generation followed by intramolecular C-C bond formation through unique reactivity of the benzimidazole moiety. The scope of this method is further extended to synthesize tetracyclic pyrroloindole benzimidazole-carboxylates through 2-carboxaldehydes.
URI: http://dx.doi.org/10.1002/adsc.201701140
http://hdl.handle.net/11536/144468
ISSN: 1615-4150
DOI: 10.1002/adsc.201701140
期刊: ADVANCED SYNTHESIS & CATALYSIS
Volume: 360
起始頁: 502
結束頁: 512
Appears in Collections:Articles