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dc.contributor.authorWu, Tz-Yien_US
dc.contributor.authorDhole, Sandipen_US
dc.contributor.authorSelvaraju, Manikandanen_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2018-08-21T05:53:26Z-
dc.date.available2018-08-21T05:53:26Z-
dc.date.issued2018-03-01en_US
dc.identifier.issn2156-8952en_US
dc.identifier.urihttp://dx.doi.org/10.1021/acscombsci.7b00170en_US
dc.identifier.urihttp://hdl.handle.net/11536/144691-
dc.description.abstractA novel and efficient method for the one-pot synthesis of 2H-indazole from readily available building blocks is reported. The reaction of 2-nitrobenzylamines with zinc and ammonium formate underwent partial reduction to nitroso-benzylamine followed by an intramolecular cyclization to afford 2H-indazole via N-N bond formation. The carboxylic acid moiety of indazole was proceeded to regioselective alkyne insertion under ruthenium catalysis to form pyranone-fused indazoles. The regioselectivity is influenced by the weak coordination of indazole ring nitrogen to the metal center.en_US
dc.language.isoen_USen_US
dc.subjectregioselective synthesisen_US
dc.subjectindazolesen_US
dc.subjectreductive cyclizationen_US
dc.subjectalkyneen_US
dc.subjectone-pot synthesisen_US
dc.titleRegioselective Synthesis of Pyranone-Fused Indazoles via Reductive Cyclization and Alkyne Insertionen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/acscombsci.7b00170en_US
dc.identifier.journalACS COMBINATORIAL SCIENCEen_US
dc.citation.volume20en_US
dc.citation.spage156en_US
dc.citation.epage163en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000427539800006en_US
Appears in Collections:Articles