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dc.contributor.authorChang, Yi-Anen_US
dc.contributor.authorWeng, Shun-Longen_US
dc.contributor.authorYang, Shun-Faen_US
dc.contributor.authorChou, Chih-Hungen_US
dc.contributor.authorHuang, Wei-Chihen_US
dc.contributor.authorTu, Siang-Jyunen_US
dc.contributor.authorChang, Tzu-Haoen_US
dc.contributor.authorHuang, Chien-Ningen_US
dc.contributor.authorJong, Yuh-Jyhen_US
dc.contributor.authorHuang, Hsien-Daen_US
dc.date.accessioned2018-08-21T05:53:28Z-
dc.date.available2018-08-21T05:53:28Z-
dc.date.issued2018-03-01en_US
dc.identifier.issn1422-0067en_US
dc.identifier.urihttp://dx.doi.org/10.3390/ijms19030758en_US
dc.identifier.urihttp://hdl.handle.net/11536/144727-
dc.description.abstractOral squamous cell carcinoma (OSCC) is often diagnosed at a late stage and may be malignantly transformed from oral leukoplakia (OL). This study aimed to identify potential plasma microRNAs (miRNAs) for the early detection of oral cancer. Plasma from normal, OL, and OSCC patients were evaluated. Small RNA sequencing was used to screen the differently expressed miRNAs among the groups. Next, these miRNAs were validated with individual samples by quantitative real-time polymerase chain reaction (qRT-PCR) assays in the training phase (n = 72) and validation phase (n = 178). The possible physiological roles of the identified miRNAs were further investigated using bioinformatics analysis. Three miRNAs (miR-222-3p, miR-150-5p, and miR-423-5p) were identified as differentially expressed among groups; miR-222-3p and miR-423-5p negatively correlated with T stage, lymph node metastasis status, and clinical stage. A high diagnostic accuracy (Area under curve = 0.88) was demonstrated for discriminating OL from OSCC. Bioinformatics analysis reveals that miR-423-5p and miR-222-3p are significantly over-expressed in oral cancer tissues and involved in various cancer pathways. The three-plasma miRNA panel may be useful to monitor malignant progression from OL to OSCC and as potential biomarkers for early detection of oral cancer.en_US
dc.language.isoen_USen_US
dc.subjectmiRNAen_US
dc.subjectbiomarkeren_US
dc.subjectoral canceren_US
dc.subjectleukoplakiaen_US
dc.subjectearly diagnosisen_US
dc.titleA Three-MicroRNA Signature as a Potential Biomarker for the Early Detection of Oral Canceren_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms19030758en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCESen_US
dc.citation.volume19en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000428309800115en_US
Appears in Collections:Articles