標題: | Simultaneous drug delivery and cellular imaging using graphene oxide |
作者: | Cheng, Sheng-Jen Chiu, Hsien-Yi Kumar, Priyank V. Hsieh, Kuan Yu Yang, Jia-Wei Lin, You-Rong Shen, Yu-Chih Chen, Guan-Yu 生物科技學系 分子醫學與生物工程研究所 資訊工程學系 Department of Biological Science and Technology Institute of Molecular Medicine and Bioengineering Department of Computer Science |
公開日期: | 1-四月-2018 |
摘要: | Graphene oxide (GO), a derivative of graphene, and its related nanomaterials have attracted much attention in recent years due to the excellent biocompatibility and large surface area of GO with abundant oxygen functional groups, which further enable it to serve as a nano- bio interface. Herein, we demonstrate the induction of blue fluorescence in GO suspensions via a mild thermal annealing procedure. Additionally, this procedure preserves the oxygen functional groups on the graphene plane which enables the conjugation of cancer drugs without obvious cytotoxicity. Consequently, we demonstrate the capability of GO to simultaneously play the dual- role of a: (i) cellular imaging agent and (ii) drug delivery agent in CT26 cancer cells without the need for additional fluorescent protein labeling. Our method offers a simple, controllable strategy to tune and enhance the fluorescence property of GO, which shows potential for biomedical applications and fundamental studies. |
URI: | http://dx.doi.org/10.1039/c7bm01192j http://hdl.handle.net/11536/144745 |
ISSN: | 2047-4830 |
DOI: | 10.1039/c7bm01192j |
期刊: | BIOMATERIALS SCIENCE |
Volume: | 6 |
起始頁: | 813 |
結束頁: | 819 |
顯示於類別: | 期刊論文 |