標題: | Magnesium oxide use and reduced risk of dementia: a retrospective, nationwide cohort study in Taiwan |
作者: | Tzeng, Nian-Sheng Chung, Chi-Hsiang Lin, Fu-Huang Huang, Ching-Feng Yeh, Chin-Bin Huang, San-Yuan Lu, Ru-Band Chang, Hsin-An Kao, Yu-Chen Yeh, Hui-Wen Chiang, Wei-Shan Chou, Yu-Ching Tsao, Chang-Huei Wu, Yung-Fu Chien, Wu-Chien 生物資訊及系統生物研究所 Institude of Bioinformatics and Systems Biology |
關鍵字: | Dementia;magnesium oxide;cohort study;propensity score;risk factors;dataset |
公開日期: | 1-一月-2018 |
摘要: | Objective: Dietary magnesium may be associated with a lower risk of dementia; however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. Methods: We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged >= 50 years with no history of MgO usage. A total of 1547 patients who had used MgO were enrolled, along with 4641 controls who had not used the MgO propensity score matched by age, gender and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10 year follow-up period. Results: Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p=.004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p=.001). Conclusions: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted. |
URI: | http://dx.doi.org/10.1080/03007995.2017.1385449 http://hdl.handle.net/11536/144761 |
ISSN: | 0300-7995 |
DOI: | 10.1080/03007995.2017.1385449 |
期刊: | CURRENT MEDICAL RESEARCH AND OPINION |
Volume: | 34 |
起始頁: | 163 |
結束頁: | 169 |
顯示於類別: | 期刊論文 |