標題: Reduced frontal activity during a verbal fluency test in fibromyalgia: A near-infrared spectroscopy study
作者: Chou, Po-Han
Tang, Kuo-Tung
Chen, Yi-Hsing
Sun, Chia-Wei
Huang, Chih-Mao
Chen, Der-Yuan
生物科技學系
光電工程學系
Department of Biological Science and Technology
Department of Photonics
關鍵字: Brain dysfunction;Cognition;Fibromyalgia;Near infrared spectroscopy;NIRS
公開日期: 1-四月-2018
摘要: Fibromyalgia (FM) is a complex disorder characterized by widespread chronic pain and associated sleep problems and cognitive dysfunction. However, only few studies focusing on cognitive dysfunction in FM are available so far. In the present study, we aimed to use near infrared spectroscopy (NIRS) to evaluate the brain function in FM patients subjected to a verbal fluency test (VFT). A total of 11 primary FM patients and 13 healthy individuals (HC) underwent NIRS while performing a VFT. The Fibromyalgia Impact Questionnaire (FIQ) was used to evaluate the symptom severity of FM and Beck Depression Inventory II (BDI) was used to evaluate the severities depression symptoms in study participants. Five regions of interests (ROIs) were defined: the frontal-, bilateral inferior frontal gyrus (IFG), and temporal regions. Brain activities of ROIs between the two groups were compared. In addition, we investigated the relationship between clinical symptoms and brain cortical activity in FM patients. Our results showed that there were no significant differences between HC and FM patients in age, sex, and BDI scores. We found significantly reduced brain activity over the frontal regions during a VFT in FM patients (p =.026). In addition, we found decreased frontal activity was associated with BDI scores (rho = -0.755, p =.007). Furthermore, there were no significant correlations between frontal activity and FIQ subscales. In conclusion, our study demonstrated a reduced frontal cortical activity during VET in FM patients, and that NIRS could be a potential tool for evaluating brain function in FM patients in clinical settings. (C) 2018 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jocn.2018.01.030
http://hdl.handle.net/11536/144811
ISSN: 0967-5868
DOI: 10.1016/j.jocn.2018.01.030
期刊: JOURNAL OF CLINICAL NEUROSCIENCE
Volume: 50
起始頁: 35
結束頁: 40
顯示於類別:期刊論文