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dc.contributor.authorTsai, Wei-Chungen_US
dc.contributor.authorChan, Yi-Hsinen_US
dc.contributor.authorChinda, Kroekkiaten_US
dc.contributor.authorChen, Zhenhuien_US
dc.contributor.authorPatel, Jheelen_US
dc.contributor.authorShen, Changyuen_US
dc.contributor.authorZhao, Yeen_US
dc.contributor.authorJiang, Zhaoleien_US
dc.contributor.authorYuan, Yuanen_US
dc.contributor.authorYe, Michaelen_US
dc.contributor.authorChen, Lan S.en_US
dc.contributor.authorRiley, Amanda A.en_US
dc.contributor.authorPersohn, Scott A.en_US
dc.contributor.authorTerrito, Paul R.en_US
dc.contributor.authorEverett, Thomas H.en_US
dc.contributor.authorLin, Shien-Fongen_US
dc.contributor.authorVinters, Harry V.en_US
dc.contributor.authorFishbein, Michael C.en_US
dc.contributor.authorChen, Peng-Shengen_US
dc.date.accessioned2018-08-21T05:53:34Z-
dc.date.available2018-08-21T05:53:34Z-
dc.date.issued2017-02-01en_US
dc.identifier.issn1547-5271en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.hrthm.2016.10.003en_US
dc.identifier.urihttp://hdl.handle.net/11536/144864-
dc.description.abstractBACKGROUND Renal sympathetic denervation (RD) is a promising method of neuromodulation for the management of cardiac arrhythmia. OBJECTIVE We tested the hypothesis that RD is antiarrhythmic in ambulatory dogs because it reduces the stellate ganglion nerve activity (SGNA) by remodeling the stellate ganglion (SG) and brain stem. METHODS We implanted a radiotransmitter to record SGNA and electrocardiogram in 9 ambulatory dogs for 2 weeks, followed by a second surgery for RD and 2 months SGNA recording. Cell death was probed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. RESULTS Integrated SGNA at baseline and 1 and 2 months after RD were 14.0 +/- 4.0, 9.3 +/- 2.8, and 9.6 +/- 2.0 mu V, respectively (P = .042). The SG from RD but not normal control dogs (n = 5) showed confluent damage. An average of 41% +/- 10% and 40% +/- 16% of ganglion cells in the left and right SG, respectively, were TUNEL positive in RD dogs compared with 0% in controls dogs (P = .005 for both). The left and right SG from RD dogs had more tyrosine hydroxylase-negative ganglion cells than did the left SG of control dogs (P = .028 and P = .047, respectively). Extensive TUNEL-positive neurons and glial cells were also noted in the medulla, associated with strongly positive glial fibrillary acidic protein staining. The distribution was heterogeneous, with more cell death in the medial than lateral aspects of the medulla. CONCLUSION Bilateral RD caused significant central and peripheral sympathetic nerve remodeling and reduced SGNA in ambulatory dogs. These findings may in part explain the antiarrhythmic effects of RD.en_US
dc.language.isoen_USen_US
dc.subjectNervous systemen_US
dc.subjectSympatheticen_US
dc.subjectTrans-synaptic degenerationen_US
dc.subjectArrhythmiaen_US
dc.subjectNeuromodulationen_US
dc.titleEffects of renal sympathetic denervation on the stellate ganglion and brain stem in dogsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.hrthm.2016.10.003en_US
dc.identifier.journalHEART RHYTHMen_US
dc.citation.volume14en_US
dc.citation.spage255en_US
dc.citation.epage262en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.identifier.wosnumberWOS:000397243400019en_US
Appears in Collections:Articles