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dc.contributor.authorLi, Zipengen_US
dc.contributor.authorLai, Kelvin Yi-Tseen_US
dc.contributor.authorYu, Po-Hsienen_US
dc.contributor.authorChakrabarty, Krishnenduen_US
dc.contributor.authorHo, Tsung-Yien_US
dc.contributor.authorLee, Chen-Yien_US
dc.date.accessioned2018-08-21T05:53:35Z-
dc.date.available2018-08-21T05:53:35Z-
dc.date.issued2018-05-01en_US
dc.identifier.issn0278-0070en_US
dc.identifier.urihttp://dx.doi.org/10.1109/TCAD.2017.2740299en_US
dc.identifier.urihttp://hdl.handle.net/11536/144898-
dc.description.abstractA digital microfluidic biochip (DMFB) is an attractive platform for immunoassays, point-of-care clinical diagnostics, DNA sequencing, and other laboratory procedures in biochemistry. More recently, DMFBs based on a micro-electrode-dot-array (MEDA) architecture have been proposed, and droplet manipulations on MEDA biochips have also been experimentally demonstrated. In order to ensure robust fluidic operations and high confidence in the outcome of biochemical experiments, MEDA biochips must be adequately tested before they can be used for bioassay execution. This paper presents the first approach for testing of MEDA biochips that include both CMOS circuits and microfluidic components. We first present structural test techniques to evaluate the pass/fail status of each microcell (droplet actuation, droplet maintenance, and droplet sensing) and identify faulty microcells. In order to ensure correct operation of functional units, e.g., mixers and diluters, we also present functional test techniques to address fundamental MEDA operations, such as droplet dispensing, transportation, mixing, and splitting. We evaluate the proposed test methods using simulations as well as experiments for fabricated MEDA biochips.en_US
dc.language.isoen_USen_US
dc.subjectDependabilityen_US
dc.subjectdigital microfluidicsen_US
dc.subjectmicroelectrode-dot-array (MEDA)en_US
dc.subjectreconfigurationen_US
dc.subjecttestingen_US
dc.titleStructural and Functional Test Methods for Micro-Electrode-Dot-Array Digital Microfluidic Biochipsen_US
dc.typeArticleen_US
dc.identifier.doi10.1109/TCAD.2017.2740299en_US
dc.identifier.journalIEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMSen_US
dc.citation.volume37en_US
dc.citation.spage968en_US
dc.citation.epage981en_US
dc.contributor.department電子工程學系及電子研究所zh_TW
dc.contributor.departmentDepartment of Electronics Engineering and Institute of Electronicsen_US
dc.identifier.wosnumberWOS:000430707000005en_US
Appears in Collections:Articles