標題: Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study
作者: Tzeng, Nian-Sheng
Chang, Hsin-An
Chung, Chi-Hsiang
Kao, Yu-Chen
Chang, Chuan-Chia
Yeh, Hui-Wen
Chiang, Wei-Shan
Chou, Yu-Ching
Chang, Shan-Yueh
Chien, Wu-Chien
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: bronchial asthma;allergic rhinitis;atopic dermatitis;psychiatric disorders;risk factors;cohort study;Taiwan National Health Insurance Program;National Health Insurance Research Database
公開日期: 24-四月-2018
摘要: Background/objective: Allergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these allergic diseases and the risk of developing overall psychiatric disorders in patients from Taiwan. Methods: This cohort study used the database of the Taiwan National Health Insurance Program. A total of 186,588 enrolled patients, with 46,647 study subjects who had suffered from allergic diseases, and 139,941 controls matched for sex and age, from the Longitudinal Health Insurance Dataset of 2000-2015, were selected from a sub-dataset of the National Health Insurance Research Database. Fine and Gray's competing risk model analysis was used to explore the hazard ratio (HR), and 95% confidence interval, for the risk of allergic diseases being associated with the risk of developing psychiatric disorders during the 15 years of follow-up. Results: Of the study subjects, 5,038 (10.8%) developed psychiatric disorders when compared to 9,376 (6.7%) in the control group, with significant difference (p < 0.001). Fine and Gray's competing risk model analysis revealed that the adjusted HR was 1.659 (95% Cl = 1.602-1.717, p < 0.001). In this study, we found that the groups of atopic dermatitis alone and the allergic rhinitis + atopic dermatitis were associated with a lower risk of psychiatric disorders, but all the other four groups, such as bronchial asthma alone, allergic rhinitis alone, bronchial asthma + allergic rhinitis, bronchial asthma + atopic dermatitis, and the combination of all these three allergic diseases, were associated with a higher risk of psychiatric disorders. Conclusion: Allergic diseases are therefore associated with a 1.66-fold increased hazard of psychiatric disorders in Taiwan.
URI: http://dx.doi.org/10.3389/fpsyt.2018.00133
http://hdl.handle.net/11536/144900
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2018.00133
期刊: FRONTIERS IN PSYCHIATRY
Volume: 9
顯示於類別:期刊論文