標題: Clonal spread of carbapenem-resistant Acinetobacter baumannii across a community hospital and its affiliated long-term care facilities: A cross sectional study
作者: Chen, Chang-Hua
Kuo, Han-Yueh
Hsu, Po-Jui
Chang, Chien-Min
Chen, Jiann-Yuan
Lu, Henry Horng-Shing
Chen, Hsin-Yao
Liou, Ming-Li
統計學研究所
Institute of Statistics
關鍵字: Carbapenem-resistant Acinetobacter baumannii;A community hospital;Long-term care facilities
公開日期: 1-Jun-2018
摘要: Background: The global spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is now a public health problem. In Taiwan, the relationship of the CRAB circulation between long-term care facilities (LTCFs) and acute care hospitals remains unclear. Here, we use molecular epidemiologic methods to describe the transmission of CRAB isolates between a community hospital and its affiliated LTCFs. Methods: Subjects localized in eight LTCFs who were not admitted acute care hospitals in recent a year were enrolled in this study. CRAB isolates were collected during June 1, 2015 and December 31, 2015. DNA fingerprinting was performed by repetitive extragenic palindromic sequence-based polymerase chain reaction (Rep-PCR) and multilocus sequence typing (MLST). Multiplex-PCR amplification for the detection of bla(OXA) genes and beta-lactamase genes was performed. Results: Twenty one subjects were enrolled. The major hospital admission diagnoses among the 21 subjects were pneumonia (71.4%). Genotyping of CRAB isolates by Rep-PCR revealed that a major clone, designated as type III, comprised fifteen of 21 (71.4%) isolates taken from 5 LTCFs and one study hospital. The isolates with type III were subtyped by PubMLST into 4 ST types. The most prevalent bla(OXA) genes in these isolates were bla(OXA-23)-like (85.70%, 18/21). Twenty isolates carried bla(SHV). Conclusion: Clonal spread of bla(OXA-23)-carrying CRABs was found around LTCFs and the affiliated hospital. In Taiwan, it is important for the government to focus attention on the importance of identifying and tracing CRAB infections in LTCFs. Copyright (C) 2017, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
URI: http://dx.doi.org/10.1016/j.jmii.2017.08.001
http://hdl.handle.net/11536/145094
ISSN: 1684-1182
DOI: 10.1016/j.jmii.2017.08.001
期刊: JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
Volume: 51
起始頁: 377
結束頁: 384
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