標題: Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes
作者: Cai, Qiang
Qiao, Lulu
Wang, Ming
He, Baoye
Lin, Feng-Mao
Palmquist, Jared
Huang, Sienna-Da
Jin, Hailing
生物科技學系
Department of Biological Science and Technology
公開日期: 8-Jun-2018
摘要: Some pathogens and pests deliver small RNAs (sRNAs) into host cells to suppress host immunity. Conversely, hosts also transfer sRNAs into pathogens and pests to inhibit their virulence. Although sRNA trafficking has been observed in a wide variety of interactions, how sRNAs are transferred, especially from hosts to pathogens and pests, is still unknown. Here, we show that host Arabidopsis cells secrete exosome-like extracellular vesicles to deliver sRNAs into fungal pathogen Botrytis cinerea. These sRNA-containing vesicles accumulate at the infection sites and are taken up by the fungal cells. Transferred host sRNAs induce silencing of fungal genes critical for pathogenicity. Thus, Arabidopsis has adapted exosome-mediated cross-kingdom RNA interference as part of its immune responses during the evolutionary arms race with the pathogen.
URI: http://dx.doi.org/10.1126/science.aar4142
http://hdl.handle.net/11536/145102
ISSN: 0036-8075
DOI: 10.1126/science.aar4142
期刊: SCIENCE
Volume: 360
起始頁: 1126
結束頁: 1129
Appears in Collections:Articles