完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang, Hsiao-Wen | en_US |
dc.contributor.author | Lin, Yen-Hung | en_US |
dc.contributor.author | Lin, Min-Hsuan | en_US |
dc.contributor.author | Huang, Ya-Rong | en_US |
dc.contributor.author | Chou, Chih-Hung | en_US |
dc.contributor.author | Hong, Hsiao-Chin | en_US |
dc.contributor.author | Wang, Mei-Ren | en_US |
dc.contributor.author | Tseng, Yu-Ting | en_US |
dc.contributor.author | Liao, Po-Chun | en_US |
dc.contributor.author | Chung, Min-Chuan | en_US |
dc.contributor.author | Ma, Yu-Jie | en_US |
dc.contributor.author | Wu, Shou-Cheng | en_US |
dc.contributor.author | Chuang, Yung-Jen | en_US |
dc.contributor.author | Wang, Horng-Dar | en_US |
dc.contributor.author | Wang, Yun-Ming | en_US |
dc.contributor.author | Huang, Hsien-Da | en_US |
dc.contributor.author | Lu, Tsai-Te | en_US |
dc.contributor.author | Liaw, Wen-Feng | en_US |
dc.date.accessioned | 2018-08-21T05:53:48Z | - |
dc.date.available | 2018-08-21T05:53:48Z | - |
dc.date.issued | 2018-07-01 | en_US |
dc.identifier.issn | 0949-8257 | en_US |
dc.identifier.uri | http://dx.doi.org/10.1007/s00775-018-1569-1 | en_US |
dc.identifier.uri | http://hdl.handle.net/11536/145165 | - |
dc.description.abstract | The ubiquitous and emerging physiology function of endogenous nitric oxide in vascular, myocardial, immune, and neuronal systems prompts chemists to develop a prodrug for the controlled delivery of center dot NO in vivo and for the translational biomedical application. Inspired by the discovery of natural [Fe(NO)(2)] motif, herein, we develop the synthetic dinitrosyl iron complexes (DNICs) [Fe-2(mu-SR)(2)(NO)(4)] (1) as a universal platform for the O-2-triggered release of center dot NO, for the regulation of center dot NO-release kinetics (half-life = 0.6-27.4 h), and for the activation of physiological function of center dot NO. Using C. elegans as a model organism, the center dot NO-delivery DNIC 1 regulates IIS signaling pathway, AMPK signaling pathway, and mitochondrial function pathway to extend the lifespan and to delay the aging process based on the lifespan analysis, SA-beta gal activity assay, and next-generation RNA sequencing analysis. This study unveils the anti-aging effect of center dot NO and develops DNICs as a chemical biology probe for the continued discovery of unprecedented NO physiology. [GRAPHICS] . | en_US |
dc.language.iso | en_US | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | Biomedicine | en_US |
dc.subject | Bioinorganic chemistry | en_US |
dc.subject | Drug delivery | en_US |
dc.subject | Aging | en_US |
dc.title | Extension of C-elegans lifespan using the center dot NO-delivery dinitrosyl iron complexes | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s00775-018-1569-1 | en_US |
dc.identifier.journal | JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | en_US |
dc.citation.volume | 23 | en_US |
dc.citation.spage | 775 | en_US |
dc.citation.epage | 784 | en_US |
dc.contributor.department | 生物科技學系 | zh_TW |
dc.contributor.department | 生物資訊及系統生物研究所 | zh_TW |
dc.contributor.department | Department of Biological Science and Technology | en_US |
dc.contributor.department | Institude of Bioinformatics and Systems Biology | en_US |
dc.identifier.wosnumber | WOS:000435951600007 | en_US |
顯示於類別: | 期刊論文 |