標題: Antibacterial gold nanoparticle-based photothermal killing of vancomycin-resistant bacteria
作者: Wang, Sin-Ge
Chen, Yen-Chun
Chen, Yu-Chie
應用化學系
Department of Applied Chemistry
關鍵字: antibacterial agents;gold nanoparticles;multivalent interactions;near infrared (NIR);photothermal;vancomycin;vancomycin-resistant Enterococci
公開日期: 1-Jun-2018
摘要: Aim: The extensive use of vancomycin has given rise to vancomycin-resistant bacterial strains, such as vancomycin-resistant Enterococci (VRE). We aim to explore potent medical treatments that can inhibit the growth of VRE. Materials & methods: Vancomycin-immobilized gold nanoparticles (Au@Van NPs) with polygonal shapes from one-pot reactions were generated within approximately 7 min. Results & discussion: The as-prepared Au NPs exhibit not only antibacterial capability but also photothermal competence. The temperature of the sample solution containing the as-prepared Au@Van NPs can be raised by approximately 15 degrees C under irradiation by a near-infrared laser (lambda = 808 nm) within 5 min. Conclusion: The required amount of vancomycin on the as-prepared Au@Van NPs combined with near-infrared irradiation for inhibiting VRE is approximately 16-fold lower than that of free-form vancomycin.
URI: http://dx.doi.org/10.2217/nnm-2017-0380
http://hdl.handle.net/11536/145267
ISSN: 1743-5889
DOI: 10.2217/nnm-2017-0380
期刊: NANOMEDICINE
Volume: 13
起始頁: 1405
結束頁: 1416
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